The Long Term Microbiota and Metabolic Status in Patients with Colorectal Cancer After Curative Colon Surgery

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2019 Jun 15

PMID 31199857

Citations 8

Authors

Xi-Hsuan Lin

Jeng-Kai Jiang

Jiing-Chyuan Luo

Chung-Chi Lin

Po-Hsiang Ting

Ueng-Cheng Yang

Yuan-Tzu Lan

Yi-Hsiang Huang

Ming-Chih Hou

Fa-Yauh Lee

Affiliations

Soon will be listed here.

Abstract

Whether there are subsequent changes of metabolic profiles and microbiota status after partial colectomy remains unknown. We evaluated and compared long-term effects of microbiota status and metabolic profiles in early colorectal cancer (CRC) patients after curative colectomy to the controls. In this cross-sectional study, we analyzed metabolic syndrome occurrence in 165 patients after curative partial colectomy with right hemicolectomy (RH) or low anterior resection (LAR) and 333 age-sex matched controls. Fecal samples from some of those with RH, LAR, and controls were analyzed by next-generation sequencing method. The occurrences of metabolic syndrome were significantly higher in patients after RH, but not LAR, when compared with the controls over the long term (> 5 years) follow-up (P = 0.020). Compared with control group, RH group showed lower bacterial diversity (P = 0.007), whereas LAR group showed significantly higher bacterial diversity at the genera level (P = 0.016). Compared with the control group, the principal component analysis revealed significant differences in bacterial genera abundance after RH and LAR (P < 0.001). Furthermore, the Firmicutes to Bacteroidetes ratio was significantly lower in the RH group than the control group (22.0% versus 49.4%, P < 0.05). In conclusion, early CRC patients after RH but not LAR were associated with a higher occurrence of metabolic syndrome than the controls during long-term follow-up. In parallel with metabolic change, patients with RH showed dysbiosis with a tendency to decreased richness and a significant decrease in the diversity of gut microbiota.

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