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Sfrp5/Wnt Pathway: A Protective Regulatory System in Atherosclerotic Cardiovascular Disease

Overview

Overview

Journal J Interferon Cytokine Res

Publisher Mary Ann Liebert

Specialty Allergy & Immunology

Date 2019 Jun 15

PMID 31199714

Citations 24

Authors

Authors

Shan Tong

Qingwei Ji

Yu Du

Xiaogang Zhu

Caizhong Zhu

Yujie Zhou

Affiliations

Affiliations

Soon will be listed here.

Abstract

Adipose tissue stores energy and is the largest endocrine organ in the body, producing several adipokines. However, among these adipokines, few play a role in the positive metabolism that promotes good health. Secreted frizzled-related protein (Sfrp)-5, an antagonist that directly binds to Wnt, has attracted interest due to its favorable effects on atherosclerotic cardiovascular disease (ASCVD). This review focuses on Sfrp5 biology and the roles of the Sfrp5/Wnt system in ASCVD.

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