Oxidative Stress and Polycystic Ovary Syndrome: A Brief Review

Overview

Journal Int J Prev Med

Date 2019 Jun 15

PMID 31198521

Citations 99

Authors

Masoumeh Mohammadi

Affiliations

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Abstract

Polycystic ovary syndrome (PCOS) is one of the most common hormonal disorders, occurring in 5-10% women in reproductive ages. Despite a long history of studies on PCOS, its etiology is still unknown. Oxidative stress is now recognized to play a central role in the pathophysiology of many different disorders, including PCOS. Although intracellular reactive oxygen species (ROS) production and propagation are controlled by highly complex antioxidant enzymatic and non-enzymatic systems, understanding of mechanisms that oxidative stress is important to develop strategies for prevention and therapy of PCOS. This article reviews the literature data related to the mechanisms of oxidative stress in PCOS.

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References

Dvorakova M, Hohler B, Vollerthun R, Fischbach T, Kummer W . Macrophages: a major source of cytochrome b558 in the rat carotid body. Brain Res. 2000; 852(2):349-54. DOI: 10.1016/s0006-8993(99)02156-3. View

Kaya C, Erkan A, Cengiz S, Dunder I, Demirel O, Bilgihan A . Advanced oxidation protein products are increased in women with polycystic ovary syndrome: relationship with traditional and nontraditional cardiovascular risk factors in patients with polycystic ovary syndrome. Fertil Steril. 2008; 92(4):1372-1377. DOI: 10.1016/j.fertnstert.2008.08.016. View

Pollak M . The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer. 2012; 12(3):159-69. DOI: 10.1038/nrc3215. View

Moran C, Tena G, Moran S, Ruiz P, Reyna R, Duque X . Prevalence of polycystic ovary syndrome and related disorders in mexican women. Gynecol Obstet Invest. 2010; 69(4):274-280. DOI: 10.1159/000277640. View

Cheng G, Cao Z, Xu X, Van Meir E, Lambeth J . Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene. 2001; 269(1-2):131-40. DOI: 10.1016/s0378-1119(01)00449-8. View

Wang X, Martindale J, Liu Y, Holbrook N . The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J. 1998; 333 ( Pt 2):291-300. PMC: 1219585. DOI: 10.1042/bj3330291. View

Boutros T, Chevet E, Metrakos P . Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev. 2008; 60(3):261-310. DOI: 10.1124/pr.107.00106. View

Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker A . Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles. Obstet Gynecol. 2003; 101(6):1177-82. DOI: 10.1016/s0029-7844(03)00233-3. View

Verit F, Erel O . Oxidative stress in nonobese women with polycystic ovary syndrome: correlations with endocrine and screening parameters. Gynecol Obstet Invest. 2008; 65(4):233-9. DOI: 10.1159/000113046. View

10.

Kurdoglu Z, Ozkol H, Tuluce Y, Koyuncu I . Oxidative status and its relation with insulin resistance in young non-obese women with polycystic ovary syndrome. J Endocrinol Invest. 2011; 35(3):317-21. DOI: 10.3275/7682. View

11.

Dib M, Garrel C, Favier A, Robin V, Desnuelle C . Can malondialdehyde be used as a biological marker of progression in neurodegenerative disease?. J Neurol. 2002; 249(4):367-74. DOI: 10.1007/s004150200025. View

12.

Isik H, Aynioglu O, Timur H, Sahbaz A, Harma M, Can M . Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?. J Reprod Immunol. 2016; 116:98-103. DOI: 10.1016/j.jri.2016.06.002. View

13.

Rashidi B, Haghollahi F, Shariat M, Zayerii F . The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol. 2009; 48(2):142-7. DOI: 10.1016/S1028-4559(09)60275-8. View

14.

Palacio J, Iborra A, Ulcova-Gallova Z, Badia R, Martinez P . The presence of antibodies to oxidative modified proteins in serum from polycystic ovary syndrome patients. Clin Exp Immunol. 2006; 144(2):217-22. PMC: 1809652. DOI: 10.1111/j.1365-2249.2006.03061.x. View

15.

Diamanti-Kandarakis E, Piperi C, Kalofoutis A, Creatsas G . Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2005; 62(1):37-43. DOI: 10.1111/j.1365-2265.2004.02170.x. View

16.

Torun A, Vural M, Cece H, Camuzcuoglu H, Toy H, Aksoy N . Paraoxonase-1 is not affected in polycystic ovary syndrome without metabolic syndrome and insulin resistance, but oxidative stress is altered. Gynecol Endocrinol. 2011; 27(12):988-92. DOI: 10.3109/09513590.2011.569798. View

17.

Brown M, Sacks D . Protein scaffolds in MAP kinase signalling. Cell Signal. 2008; 21(4):462-9. PMC: 2668224. DOI: 10.1016/j.cellsig.2008.11.013. View

18.

Seleem A, El Refaeey A, Shaalan D, Sherbiny Y, Badawy A . Superoxide dismutase in polycystic ovary syndrome patients undergoing intracytoplasmic sperm injection. J Assist Reprod Genet. 2014; 31(4):499-504. PMC: 3969459. DOI: 10.1007/s10815-014-0190-7. View

19.

Allen R, Tresini M . Oxidative stress and gene regulation. Free Radic Biol Med. 2000; 28(3):463-99. DOI: 10.1016/s0891-5849(99)00242-7. View

20.

Gonzalez F, Rote N, Minium J, Kirwan J . Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J Clin Endocrinol Metab. 2005; 91(1):336-40. DOI: 10.1210/jc.2005-1696. View