Dispositional Negativity, Cognition, and Anxiety Disorders: An Integrative Translational Neuroscience Framework

Overview

Journal Prog Brain Res

Publisher Elsevier

Specialty Neurology

Date 2019 Jun 15

PMID 31196442

Citations 48

Authors

Juyoen Hur

Melissa D Stockbridge

Andrew S Fox

Alexander J Shackman

Affiliations

Soon will be listed here.

Abstract

When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.

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References

Davey Smith G, Ebrahim S . What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?. BMJ. 2005; 330(7499):1076-9. PMC: 557238. DOI: 10.1136/bmj.330.7499.1076. View

Watson D, Nus E, Wu K . Development and Validation of the Faceted Inventory of the Five-Factor Model (FI-FFM). Assessment. 2017; 26(1):17-44. DOI: 10.1177/1073191117711022. View

Woo C, Chang L, Lindquist M, Wager T . Building better biomarkers: brain models in translational neuroimaging. Nat Neurosci. 2017; 20(3):365-377. PMC: 5988350. DOI: 10.1038/nn.4478. View

Macleod C, Grafton B . Anxiety-linked attentional bias and its modification: Illustrating the importance of distinguishing processes and procedures in experimental psychopathology research. Behav Res Ther. 2016; 86:68-86. DOI: 10.1016/j.brat.2016.07.005. View

Perez-Edgar K, Reeb-Sutherland B, McDermott J, White L, Henderson H, Degnan K . Attention biases to threat link behavioral inhibition to social withdrawal over time in very young children. J Abnorm Child Psychol. 2011; 39(6):885-95. PMC: 3756613. DOI: 10.1007/s10802-011-9495-5. View

Damian R, Su R, Shanahan M, Trautwein U, Roberts B . Can personality traits and intelligence compensate for background disadvantage? Predicting status attainment in adulthood. J Pers Soc Psychol. 2014; 109(3):473-89. PMC: 4433862. DOI: 10.1037/pspp0000024. View

Derakshan N, Smyth S, Eysenck M . Effects of state anxiety on performance using a task-switching paradigm: an investigation of attentional control theory. Psychon Bull Rev. 2009; 16(6):1112-7. DOI: 10.3758/PBR.16.6.1112. View

Minxha J, Mosher C, Morrow J, Mamelak A, Adolphs R, Gothard K . Fixations Gate Species-Specific Responses to Free Viewing of Faces in the Human and Macaque Amygdala. Cell Rep. 2017; 18(4):878-891. PMC: 5283067. DOI: 10.1016/j.celrep.2016.12.083. View

Oler J, Fox A, Shelton S, Christian B, Murali D, Oakes T . Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. J Neurosci. 2009; 29(32):9961-6. PMC: 2756094. DOI: 10.1523/JNEUROSCI.0795-09.2009. View

10.

Sharko A, Kaigler K, Fadel J, Wilson M . Ethanol-induced anxiolysis and neuronal activation in the amygdala and bed nucleus of the stria terminalis. Alcohol. 2016; 50:19-25. PMC: 4753081. DOI: 10.1016/j.alcohol.2015.11.001. View

11.

Davey Smith G . Mendelian Randomization for Strengthening Causal Inference in Observational Studies: Application to Gene × Environment Interactions. Perspect Psychol Sci. 2015; 5(5):527-45. DOI: 10.1177/1745691610383505. View

12.

Tottenham N, Gabard-Durnam L . The developing amygdala: a student of the world and a teacher of the cortex. Curr Opin Psychol. 2017; 17:55-60. PMC: 5657533. DOI: 10.1016/j.copsyc.2017.06.012. View

13.

Mueller S, Wagner J, Smith J, Voelkle M, Gerstorf D . The interplay of personality and functional health in old and very old age: Dynamic within-person interrelations across up to 13 years. J Pers Soc Psychol. 2017; 115(6):1127-1147. DOI: 10.1037/pspp0000173. View

14.

Glahn D, Curran J, Winkler A, Carless M, Kent Jr J, Charlesworth J . High dimensional endophenotype ranking in the search for major depression risk genes. Biol Psychiatry. 2011; 71(1):6-14. PMC: 3230692. DOI: 10.1016/j.biopsych.2011.08.022. View

15.

Pichon S, Miendlarzewska E, Eryilmaz H, Vuilleumier P . Cumulative activation during positive and negative events and state anxiety predicts subsequent inertia of amygdala reactivity. Soc Cogn Affect Neurosci. 2014; 10(2):180-90. PMC: 4321619. DOI: 10.1093/scan/nsu044. View

16.

Fox A, Oler J, Shelton S, Nanda S, Davidson R, Roseboom P . Central amygdala nucleus (Ce) gene expression linked to increased trait-like Ce metabolism and anxious temperament in young primates. Proc Natl Acad Sci U S A. 2012; 109(44):18108-13. PMC: 3497741. DOI: 10.1073/pnas.1206723109. View

17.

Chang L, Gianaros P, Manuck S, Krishnan A, Wager T . A Sensitive and Specific Neural Signature for Picture-Induced Negative Affect. PLoS Biol. 2015; 13(6):e1002180. PMC: 4476709. DOI: 10.1371/journal.pbio.1002180. View

18.

Bocanegra B, Zeelenberg R . Emotion-induced trade-offs in spatiotemporal vision. J Exp Psychol Gen. 2011; 140(2):272-82. DOI: 10.1037/a0023188. View

19.

Hermans E, Kanen J, Tambini A, Fernandez G, Davachi L, Phelps E . Persistence of Amygdala-Hippocampal Connectivity and Multi-Voxel Correlation Structures During Awake Rest After Fear Learning Predicts Long-Term Expression of Fear. Cereb Cortex. 2016; 27(5):3028-3041. PMC: 6059183. DOI: 10.1093/cercor/bhw145. View

20.

Macleod C . Anxiety-linked attentional bias: backward glances and future glimpses. Cogn Emot. 2018; 33(1):139-145. DOI: 10.1080/02699931.2018.1551190. View