Utility and Predictive Value of Human Standard Semen Parameters and Sperm DNA Dispersion for Fertility Potential

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2019 Jun 15

PMID 31195656

Citations 14

Authors

Kamil Gill

Joanna Jakubik

Aleksandra Rosiak-Gill

Michal Kups

Mariusz Lukaszuk

Maciej Kurpisz

Monika Fraczek

Malgorzata Piasecka

Affiliations

Soon will be listed here.

Abstract

Because the assessment of sperm DNA fragmentation (SDF) plays a key role in male fertility, our study was designed to find the relationships between SDF and standard semen parameters. The receiver operating characteristic (ROC) curve showed that 18% SDF is a prognostic parameter for discriminating between men with normal and abnormal standard semen parameters (n = 667). Men with > 18% SDF had significantly lower quality semen, a higher prevalence of abnormal semen characteristics, and a higher odds ratio for abnormal semen parameters compared to men with ≤ 18% SDF. An ROC analysis provided predictive values for age and semen parameters to distinguish between men with SDF > 18% and men with ≤ 18% SDF. SDF was positively correlated with male age and teratozoospermia index but negatively with sperm concentration, total number of spermatozoa, sperm morphology, progressive motility, and vitality. Our study shows that 18% SDF has a predictive value for distinguishing between men with normal and abnormal semen characteristics. Men with >18% SDF have a higher risk for abnormal semen parameters, while age and obtained semen parameters have a predictive value for SDF. There is a relationship between SDF and conventional sperm characteristics, and thus, SDF can be incorporated into male fertility assessment.

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References

Agarwal A, Panner Selvam M, Baskaran S, Cho C . Sperm DNA damage and its impact on male reproductive health: a critical review for clinicians, reproductive professionals and researchers. Expert Rev Mol Diagn. 2019; 19(6):443-457. DOI: 10.1080/14737159.2019.1614916. View

Inhorn M, Patrizio P . Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015; 21(4):411-26. DOI: 10.1093/humupd/dmv016. View

Cho C, Agarwal A, Majzoub A, Esteves S . Clinical utility of sperm DNA fragmentation testing: concise practice recommendations. Transl Androl Urol. 2017; 6(Suppl 4):S366-S373. PMC: 5643614. DOI: 10.21037/tau.2017.07.28. View

Agarwal A, Mulgund A, Hamada A, Chyatte M . A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015; 13:37. PMC: 4424520. DOI: 10.1186/s12958-015-0032-1. View

Evenson D, Larson K, Jost L . Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl. 2002; 23(1):25-43. DOI: 10.1002/j.1939-4640.2002.tb02599.x. View

Evgeni E, Charalabopoulos K, Asimakopoulos B . Human sperm DNA fragmentation and its correlation with conventional semen parameters. J Reprod Infertil. 2014; 15(1):2-14. PMC: 3955419. View

Simon L, Emery B, Carrell D . Review: Diagnosis and impact of sperm DNA alterations in assisted reproduction. Best Pract Res Clin Obstet Gynaecol. 2017; 44:38-56. DOI: 10.1016/j.bpobgyn.2017.07.003. View

Uppangala S, Pudakalakatti S, DSouza F, Salian S, Kalthur G, Kumar P . Influence of sperm DNA damage on human preimplantation embryo metabolism. Reprod Biol. 2016; 16(3):234-241. DOI: 10.1016/j.repbio.2016.07.004. View

Gill K, Rosiak A, Gaczarzewicz D, Jakubik J, Kurzawa R, Kazienko A . The effect of human sperm chromatin maturity on ICSI outcomes. Hum Cell. 2018; 31(3):220-231. DOI: 10.1007/s13577-018-0203-4. View

10.

Bonde J . Male reproductive organs are at risk from environmental hazards. Asian J Androl. 2009; 12(2):152-6. PMC: 3739096. DOI: 10.1038/aja.2009.83. View

11.

Shamsi M, Imam S, Dada R . Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility. J Assist Reprod Genet. 2011; 28(11):1073-85. PMC: 3224170. DOI: 10.1007/s10815-011-9631-8. View

12.

Jerre E, Bungum M, Evenson D, Giwercman A . Sperm chromatin structure assay high DNA stainability sperm as a marker of early miscarriage after intracytoplasmic sperm injection. Fertil Steril. 2019; 112(1):46-53.e2. DOI: 10.1016/j.fertnstert.2019.03.013. View

13.

Evgeni E, Lymberopoulos G, Touloupidis S, Asimakopoulos B . Sperm nuclear DNA fragmentation and its association with semen quality in Greek men. Andrologia. 2015; 47(10):1166-74. DOI: 10.1111/and.12398. View

14.

Sharma R, Agarwal A, Rohra V, Assidi M, Abu-Elmagd M, Turki R . Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reprod Biol Endocrinol. 2015; 13:35. PMC: 4455614. DOI: 10.1186/s12958-015-0028-x. View

15.

Erenpreiss J, Elzanaty S, Giwercman A . Sperm DNA damage in men from infertile couples. Asian J Androl. 2008; 10(5):786-90. DOI: 10.1111/j.1745-7262.2008.00417.x. View

16.

Cho C, Agarwal A . Role of sperm DNA fragmentation in male factor infertility: A systematic review. Arab J Urol. 2018; 16(1):21-34. PMC: 5922225. DOI: 10.1016/j.aju.2017.11.002. View

17.

Anifandis G, Bounartzi T, Messini C, Dafopoulos K, Markandona R, Sotiriou S . Sperm DNA fragmentation measured by Halosperm does not impact on embryo quality and ongoing pregnancy rates in IVF/ICSI treatments. Andrologia. 2014; 47(3):295-302. DOI: 10.1111/and.12259. View

18.

Evgeni E, Lymberopoulos G, Gazouli M, Asimakopoulos B . Conventional semen parameters and DNA fragmentation in relation to fertility status in a Greek population. Eur J Obstet Gynecol Reprod Biol. 2015; 188:17-23. DOI: 10.1016/j.ejogrb.2015.02.026. View

19.

Kaarouch I, Bouamoud N, Madkour A, Louanjli N, Saadani B, Assou S . Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years. Mol Reprod Dev. 2018; 85(3):271-280. DOI: 10.1002/mrd.22963. View

20.

Giwercman A, Lindstedt L, Larsson M, Bungum M, Spano M, Levine R . Sperm chromatin structure assay as an independent predictor of fertility in vivo: a case-control study. Int J Androl. 2009; 33(1):e221-7. DOI: 10.1111/j.1365-2605.2009.00995.x. View