Article: LINE1 and methylation of the adult striatum and prefrontal cortex exposed to prenatal immune activation

Prenatal exposure to infection and inflammation increases the risk of neurodevelopmental disorders such as schizophrenia and autism. The etiology could be partly through transgenerational and modifiable DNA methylation changes in the adult offspring's brain. This data descriptor presents a dataset of global DNA methylation (using LINE1 assay) and promoter methylation in adolescent and adult brain tissue of offspring exposed to prenatal immune activation on gestation day 9 and offspring of saline exposed mice. PCR based methylation assays using Sequenom EpiTYPER was used to quantify DNA methylation at promoter CpG methylation of Long Interspersed Elements-1 (LINE1 or L1) and . The dataset also includes global DNA methylation and promoter methylation profile at 6 and 12 weeks following early dietary intervention with omega-3 (n-3) PUFA.

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LINE1 and Methylation of the Adult Striatum and Prefrontal Cortex Exposed to Prenatal Immune Activation