Design, Synthesis, and Antimicrobial Evaluation of 1,4-dihydroindeno[1,2-]pyrazole Tethered Carbohydrazide Hybrids: Exploring Their ADMET, Ergosterol Inhibition and ROS Inducing Potential

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Jun 14

PMID 31191871

Citations 4

Authors

Mohd Adil Shareef

K Sirisha

Irfan Khan

Ibrahim Bin Sayeed

Surender Singh Jadav

Gopathi Ramu

C Ganesh Kumar

Ahmed Kamal

Bathini Nagendra Babu

Affiliations

Soon will be listed here.

Abstract

A series of new 1,4-dihydroindeno[1,2-]pyrazole tethered carbohydrazide hybrids () were designed, synthesized and evaluated for their antimicrobial activity. Compounds , , , and demonstrated significant activity against the entire panel of test pathogens. Further, compounds and exhibited significant anti- activity. These potential hybrids ( and ) also exhibited promising ergosterol biosynthesis inhibition against , which was further validated through molecular docking studies. Furthermore, compounds and caused intracellular ROS accumulation in MTCC 3017 and were non-toxic to normal human lung cell line MRC5. studies revealed that they demonstrated drug likeness and an appreciable pharmacokinetic profile. Overall, the findings demonstrate that and may be considered as promising leads for further development of new antifungal drugs.

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