» Articles » PMID: 31191684

Oct4 Gene Expression in Primary Colorectal Cancer Promotes Liver Metastasis

Overview
Journal Stem Cells Int
Publisher Wiley
Specialty Cell Biology
Date 2019 Jun 14
PMID 31191684
Citations 26
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose: The gene plays an important role in undifferentiated embryonic stem cells and regulates stem cell pluripotency. The aim of this study was to examine the relationship between Oct4 expression and liver metastasis of colorectal cancer (CRC) in clinical samples and investigate the role and abilities of Oct4-positive CRC cells.

Methods: The study included 158 patients who underwent surgery for CRC between 2009 and 2011. The correlations between the gene expression and the clinical parameters were assessed, and liver metastasis-free survival (LMFS) was evaluated in these patients. Oct4-EGFP-positive cells were established to examine their subpopulation and ability. The capacity to form liver metastasis in vivo was examined using CRC cell lines and primary cultured CRC cells.

Results: LMFS was significantly poor in the high-expression group compared with the low-expression group ( = 0.008). Multivariate analyses showed that expression ( = 0.015) and TNM stage ( < 0.001) were significantly correlated with LMFS. Oct4-EGFP-positive cells highly expressed stem cell-associated markers and had self-renewal and differentiation abilities. Oct4-high cells actively formed liver metastasis.

Conclusion: The Oct4 expression was correlated with liver metastasis in CRC patients. Oct4 expression cells have self-renewal and differentiation abilities like those of cancer stem cells. Oct4 contributed to forming liver metastasis in CRC.

Citing Articles

Inflammation-Associated Stem Cells in Gastrointestinal Cancers: Their Utility as Prognostic Biomarkers and Therapeutic Targets.

Kumari B, Tiwari A, Meena S, Ahirwar D Cancers (Basel). 2024; 16(18).

PMID: 39335106 PMC: 11429849. DOI: 10.3390/cancers16183134.


Intricate relationship between cancer stemness, metastasis, and drug resistance.

Dakal T, Bhushan R, Xu C, Gadi B, Cameotra S, Yadav V MedComm (2020). 2024; 5(10):e710.

PMID: 39309691 PMC: 11416093. DOI: 10.1002/mco2.710.


From mitochondria to tumor suppression: ACAT1's crucial role in gastric cancer.

He W, Li Y, Liu S, Chang Y, Han S, Han X Front Immunol. 2024; 15:1449525.

PMID: 39247186 PMC: 11377227. DOI: 10.3389/fimmu.2024.1449525.


Molecular subtypes of colorectal cancer in the era of precision oncotherapy: Current inspirations and future challenges.

Dang Q, Zuo L, Hu X, Zhou Z, Chen S, Liu S Cancer Med. 2024; 13(14):e70041.

PMID: 39054866 PMC: 11272957. DOI: 10.1002/cam4.70041.


Reprogramming and multi-lineage transdifferentiation attenuate the tumorigenicity of colorectal cancer cells.

Guo T, Wang J, Pang M, Liu W, Zhang X, Fan A J Biol Chem. 2023; 300(1):105534.

PMID: 38072050 PMC: 10801221. DOI: 10.1016/j.jbc.2023.105534.


References
1.
Loh Y, Wu Q, Chew J, Vega V, Zhang W, Chen X . The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006; 38(4):431-40. DOI: 10.1038/ng1760. View

2.
Katoh M, Katoh M . WNT signaling pathway and stem cell signaling network. Clin Cancer Res. 2007; 13(14):4042-5. DOI: 10.1158/1078-0432.CCR-06-2316. View

3.
Kim J, Jee M, Lee S, Han T, Kim B, Kang K . Regulation of adipose tissue stromal cells behaviors by endogenic Oct4 expression control. PLoS One. 2009; 4(9):e7166. PMC: 2747014. DOI: 10.1371/journal.pone.0007166. View

4.
Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F . Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A. 2009; 107(1):40-5. PMC: 2806714. DOI: 10.1073/pnas.0912407107. View

5.
Chiou S, Wang M, Chou Y, Chen C, Hong C, Hsieh W . Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 2010; 70(24):10433-44. DOI: 10.1158/0008-5472.CAN-10-2638. View