Adipose Tissue-Resident Immune Cells in Obesity and Type 2 Diabetes

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Jun 14

PMID 31191541

Citations 76

Authors

Jingli Lu

Junjie Zhao

Haiyang Meng

Xiaojian Zhang

Affiliations

Soon will be listed here.

Abstract

Inflammation is an important contributor to the pathogenesis of obesity-related type 2 diabetes (T2D). Adipose tissue-resident immune cells have been observed, and the potential contribution of these cells to metabolic dysfunction has been appreciated in recent years. This review focused on adipose tissue-resident immune cells that are dysregulated in the context of obesity and T2D. We comprehensively overviewed emerging knowledge regarding the phenotypic and functional properties of these cells and local factors that control their development. We discussed their function in controlling the immune response cascade and disease progression. We also characterized the metabolic profiles of these cells to explain the functional consequences in obese adipose tissues. Finally, we discussed the potential therapeutic targeting of adipose tissue-resident immune cells with the aim of addressing novel therapeutic approaches for the treatment of this disease.

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