Repair of Adult Mammalian Heart After Damages by Oral Intake of Gu Ben Pei Yuan San

Overview

Journal Front Physiol

Date 2019 Jun 14

PMID 31191336

Citations 5

Authors

Baiping Cui

Yufan Zheng

Xinyan Zhou

Jiaqi Zhu

Jiexian Zhuang

Qianqian Liang

Chen Xu

Wei Sheng

Guoying Huang

Lina Luan

Ning Sun

Affiliations

Soon will be listed here.

Abstract

Adult mammalian heart repair after myocardial damage is highly inefficient due to the post-mitotic nature of cardiomyocytes. Interestingly, in traditional Chinese medicine (TCM), there are reported effective treatments of myocardial infarction (MI) and heart failure in adult humans by oral intake of a TCM concoction named Gu Ben Pei Yuan San (GBPYS), which is composed of , velvet antler, Linnaeus tail, human placenta, Trogopterus dung, , and amber. We fed mice with GBPYS after myocardial damages through everyday self-feeding. We then examined the effect of everyday oral intake of GBPYS on improving cardiac function and myocardial repair in adult mice after apical resection or MI. We found that long-term oral intake of GBPYS significantly improved cardiac function after myocardial damages in adult mice. BrdU, phospho-histone 3, and AuroraB staining indicated increased cell proliferation at the border zone of MI after TCM feeding. GBPYS feeding reduced organ inflammation, induced angiogenesis, and is non-toxic to mice after long-term oral intake. Further, serum derived from TCM-fed MI rats promoted division of both neonatal rat cardiomyocytes and human induced pluripotent stem cell (iPSC)-derived cardiomyocytes . Oral intake of GBPYS improved heart repair after myocardial damages in adult mice. Our results suggest that there are substances present in GBPYS that help improve adult mammalian heart repair after MI. Also, it could be a good choice of non-invasive alternative therapy for myocardial damages and heart failure after rigorous clinical study in the future.

Citing Articles

Shen'ge Formula Protects Cardiac Function in Rats with Pressure Overload-Induced Heart Failure.

Qiu B, Qiao S, Shi X, Shen L, Deng B, Ma Z Drug Des Devel Ther. 2024; 18:1875-1890.

PMID: 38831869 PMC: 11146625. DOI: 10.2147/DDDT.S451720.

Chick early amniotic fluid component improves heart function and protects against inflammation after myocardial infarction in mice.

Wang J, Chen X, Zhang L, Zheng Y, Qian J, Sun N Front Cardiovasc Med. 2022; 9:1042852.

PMID: 36465449 PMC: 9710540. DOI: 10.3389/fcvm.2022.1042852.

Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.

Wang Y, Xue Y, Guo H Front Pharmacol. 2022; 13:1013740.

PMID: 36330092 PMC: 9622800. DOI: 10.3389/fphar.2022.1013740.

Transcriptomics- and metabolomics-based integration analyses revealed the potential pharmacological effects and functional pattern of in vivo Radix Paeoniae Alba administration.

Wang S, Chen H, Zheng Y, Li Z, Cui B, Zhao P Chin Med. 2020; 15:52.

PMID: 32489401 PMC: 7245909. DOI: 10.1186/s13020-020-00330-0.

Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury.

Zheng Y, Cui B, Sun W, Wang S, Huang X, Gao H Int J Biol Sci. 2020; 16(7):1166-1179.

PMID: 32174792 PMC: 7053327. DOI: 10.7150/ijbs.41293.

References

Sabbah H, Sharov V, Gupta R, Todor A, Singh V, Goldstein S . Chronic therapy with metoprolol attenuates cardiomyocyte apoptosis in dogs with heart failure. J Am Coll Cardiol. 2000; 36(5):1698-705. DOI: 10.1016/s0735-1097(00)00913-x. View

Poss K, Wilson L, Keating M . Heart regeneration in zebrafish. Science. 2002; 298(5601):2188-90. DOI: 10.1126/science.1077857. View

Dor Y, Djonov V, Keshet E . Induction of vascular networks in adult organs: implications to proangiogenic therapy. Ann N Y Acad Sci. 2003; 995:208-16. DOI: 10.1111/j.1749-6632.2003.tb03224.x. View

Annex B, Simons M . Growth factor-induced therapeutic angiogenesis in the heart: protein therapy. Cardiovasc Res. 2005; 65(3):649-55. DOI: 10.1016/j.cardiores.2004.09.004. View

Yao C, Prevel P, Koch S, Schenck P, Noah E, Pallua N . Modification of collagen matrices for enhancing angiogenesis. Cells Tissues Organs. 2005; 178(4):189-96. DOI: 10.1159/000083730. View

Padwal R, Majumdar S . Drug treatments for obesity: orlistat, sibutramine, and rimonabant. Lancet. 2007; 369(9555):71-7. DOI: 10.1016/S0140-6736(07)60033-6. View

Kikuchi K, Holdway J, Werdich A, Anderson R, Fang Y, Egnaczyk G . Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010; 464(7288):601-5. PMC: 3040215. DOI: 10.1038/nature08804. View

Porrello E, Mahmoud A, Simpson E, Hill J, Richardson J, Olson E . Transient regenerative potential of the neonatal mouse heart. Science. 2011; 331(6020):1078-80. PMC: 3099478. DOI: 10.1126/science.1200708. View

Wang Y, Liu Z, Li C, Li D, Ouyang Y, Yu J . Drug target prediction based on the herbs components: the study on the multitargets pharmacological mechanism of qishenkeli acting on the coronary heart disease. Evid Based Complement Alternat Med. 2012; 2012:698531. PMC: 3310183. DOI: 10.1155/2012/698531. View

10.

Lian X, Zhang J, Azarin S, Zhu K, Hazeltine L, Bao X . Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc. 2012; 8(1):162-75. PMC: 3612968. DOI: 10.1038/nprot.2012.150. View

11.

Li X, Zhang J, Huang J, Ma A, Yang J, Li W . A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure. J Am Coll Cardiol. 2013; 62(12):1065-1072. DOI: 10.1016/j.jacc.2013.05.035. View

12.

Burchfield J, Xie M, Hill J . Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation. 2013; 128(4):388-400. PMC: 3801217. DOI: 10.1161/CIRCULATIONAHA.113.001878. View

13.

Xie M, Burchfield J, Hill J . Pathological ventricular remodeling: therapies: part 2 of 2. Circulation. 2013; 128(9):1021-30. PMC: 3829603. DOI: 10.1161/CIRCULATIONAHA.113.001879. View

14.

Leone M, Magadum A, Engel F . Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations. Am J Physiol Heart Circ Physiol. 2015; 309(8):H1237-50. DOI: 10.1152/ajpheart.00559.2015. View

15.

Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X . Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials. 2016; 105:52-65. DOI: 10.1016/j.biomaterials.2016.07.035. View

16.

Nakada Y, Canseco D, Thet S, Abdisalaam S, Asaithamby A, Santos C . Hypoxia induces heart regeneration in adult mice. Nature. 2016; 541(7636):222-227. DOI: 10.1038/nature20173. View

17.

Bassat E, Eid Mutlak Y, Genzelinakh A, Shadrin I, Umansky K, Yifa O . The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 2017; 547(7662):179-184. PMC: 5769930. DOI: 10.1038/nature22978. View

18.

Deng S, Zhao Q, Zhen L, Zhang C, Liu C, Wang G . Neonatal Heart-Enriched miR-708 Promotes Proliferation and Stress Resistance of Cardiomyocytes in Rodents. Theranostics. 2017; 7(7):1953-1965. PMC: 5479282. DOI: 10.7150/thno.16478. View

19.

Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H . Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cell Res Ther. 2017; 8(1):202. PMC: 5622416. DOI: 10.1186/s13287-017-0651-x. View

20.

Leach J, Heallen T, Zhang M, Rahmani M, Morikawa Y, Hill M . Hippo pathway deficiency reverses systolic heart failure after infarction. Nature. 2017; 550(7675):260-264. PMC: 5729743. DOI: 10.1038/nature24045. View