Plant-based Vaccines for Alzheimer's Disease
Overview
Authors
Affiliations
Alzheimer's disease (AD) is one of the major causes of chronic and progressive cognitive decline, with the pathological hallmarks of senile plaques and neurofibrillary tangles. Amyloid β peptide (Aβ) is the main component of senile plaques, and the pathological load of Aβ in the brain has been shown to be a marker of the severity of AD. To prevent the accumulation of plaques, novel and safer plant-based vaccine strategies have been suggested. In this review, we summarize the results of plant vaccines against Aβ.
Vo D, Trinh K Vaccines (Basel). 2025; 13(2).
PMID: 40006737 PMC: 11860421. DOI: 10.3390/vaccines13020191.
Current Advances of Plant-Based Vaccines for Neurodegenerative Diseases.
Bravo-Vazquez L, Mora-Hernandez E, Rodriguez A, Sahare P, Bandyopadhyay A, Duttaroy A Pharmaceutics. 2023; 15(2).
PMID: 36840033 PMC: 9963606. DOI: 10.3390/pharmaceutics15020711.
Immunotherapies for Alzheimer's Disease-A Review.
Valiukas Z, Ephraim R, Tangalakis K, Davidson M, Apostolopoulos V, Feehan J Vaccines (Basel). 2022; 10(9).
PMID: 36146605 PMC: 9503401. DOI: 10.3390/vaccines10091527.
Dobrica M, van Eerde A, tucureanu C, Onu A, Paruch L, Caras I Plant Biotechnol J. 2021; 19(10):2027-2039.
PMID: 34002936 PMC: 8486241. DOI: 10.1111/pbi.13631.