Differential Effects of the Methylenetetrahydrofolate Reductase Polymorphisms (C677T and A1298C) on Hematological Malignancies Among Latinos: a Meta-analysis

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2019 Jun 13

PMID 31188929

Citations 1

Authors

Samanta Celeste Garcia-Hernandez

Perla Meneses-Sanchez

Leonardo Martin Porchia

Enrique Torres-Rasgado

Ricardo Perez-Fuentes

Martha Elba Gonzalez-Mejia

Affiliations

Soon will be listed here.

Abstract

Our objective was to determine the association between the methylenetetrahydrofolate reductase polymorphisms (C677T and A1298C) and the risk of developing acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and multiple myelomas (MM) in Latinos. PubMed, SCOPUS, EBSCO, LILACS, and other Latin-specific databases were searched for case-control studies that investigated the association between these polymorphisms and hematologic malignancies until November 2017. Genotype distributions were extracted and either fixed-effects or random-effects models were used to calculate the pooled crude odds ratios (ORs) for the heterozygous, homozygous, dominant, recessive, and allelic genetic models. No publication bias was detected by the Begg-Mazumdar's test and Egger's test. From 290 publications, we identified 15 studies on the C677T polymorphism and 13 studies on the A1298C polymorphism. We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models. No associations were determined for CML, AML, or MM for either polymorphism. This meta-analysis demonstrated that the A1298C polymorphism was associated with an increased risk of developing ALL, whereas the C677T polymorphism was associated with a decreased risk (protective factor) in the Latino population.

Citing Articles

Incidence and Mortality Rates for Childhood Acute Lymphoblastic Leukemia in Puerto Rican Hispanics, 2012-2016.

Montes-Rodriguez I, Soto-Salgado M, Torres-Cintron C, Tomassini-Fernandini J, Suarez E, Clavell L Cancer Epidemiol Biomarkers Prev. 2023; 32(8):1030-1037.

PMID: 37222662 PMC: 10524932. DOI: 10.1158/1055-9965.EPI-22-1227.

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