Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study

Overview

Journal Case Rep Dermatol Med

Publisher Wiley

Specialty Dermatology

Date 2019 Jun 13

PMID 31186972

Citations 18

Authors

Rajasekar Seetharaman

Anjum Mahmood

Prashant Kshatriya

Divyang Patel

Anand Srivastava

Affiliations

Soon will be listed here.

Abstract

Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. In this report, we discuss our findings about a scalp psoriasis suffering patient with a Psoriasis Scalp Severity Index (PSSI) score of 28, who was treated with Mesenchymal stem cell conditioned media (MSC-CM). Remarkably, complete regression was recorded within a treatment period of one month only (PSSI score of 0). A number of bioactive factors like cytokines and growth factors secreted by MSCs in the conditioned medium are very likely to be the principle molecules which play a vital role in skin regeneration. Treatment using MSC-CM appears to be an effective tool for tackling the psoriatic problem and, thus, may offer a new avenue of therapy which could be considered as an alternative approach to overcome the limitations of the cell-based therapy.

Citing Articles

Psoriasis: The Versatility of Mesenchymal Stem Cell and Exosome Therapies.

Dairov A, Sekenova A, Alimbek S, Nurkina A, Shakhatbayev M, Kumasheva V Biomolecules. 2024; 14(11).

PMID: 39595528 PMC: 11591958. DOI: 10.3390/biom14111351.

Therapeutic potential of adipose derived stromal cells for major skin inflammatory diseases.

Galera M, Svalgaard J, Woetmann A Front Med (Lausanne). 2024; 11:1298229.

PMID: 38463491 PMC: 10921940. DOI: 10.3389/fmed.2024.1298229.

Adipose-derived stem cells in immune-related skin disease: a review of current research and underlying mechanisms.

Sun T, Zhou C, Lu F, Dong Z, Gao J, Li B Stem Cell Res Ther. 2024; 15(1):37.

PMID: 38331803 PMC: 10854049. DOI: 10.1186/s13287-023-03561-8.

IL-6 and TGF-β-Secreting Adoptively-Transferred Murine Mesenchymal Stromal Cells Accelerate Healing of Psoriasis-like Skin Inflammation and Upregulate IL-17A and TGF-β.

Cuesta-Gomez N, Medina-Ruiz L, Graham G, Campbell J Int J Mol Sci. 2023; 24(12).

PMID: 37373278 PMC: 10298958. DOI: 10.3390/ijms241210132.

Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future.

Ramji H, Hafiz M, Hammad Altaq H, Hussain S, Chaudry F Diagnostics (Basel). 2023; 13(9).

PMID: 37174920 PMC: 10177247. DOI: 10.3390/diagnostics13091528.

References

Menter A, Griffiths C . Current and future management of psoriasis. Lancet. 2007; 370(9583):272-284. DOI: 10.1016/S0140-6736(07)61129-5. View

Chen L, Tredget E, Wu P, Wu Y . Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One. 2008; 3(4):e1886. PMC: 2270908. DOI: 10.1371/journal.pone.0001886. View

Menter A, Gottlieb A, Feldman S, Van Voorhees A, Leonardi C, Gordon K . Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics. J Am Acad Dermatol. 2008; 58(5):826-50. DOI: 10.1016/j.jaad.2008.02.039. View

Kim W, Park B, Sung J . Protective role of adipose-derived stem cells and their soluble factors in photoaging. Arch Dermatol Res. 2009; 301(5):329-36. DOI: 10.1007/s00403-009-0951-9. View

Walter M, Wright K, Fuller H, MacNeil S, Johnson W . Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays. Exp Cell Res. 2010; 316(7):1271-81. DOI: 10.1016/j.yexcr.2010.02.026. View

Lee M, Kim J, Lee K, Shin J, Chae J, Chung H . Enhancement of wound healing by secretory factors of endothelial precursor cells derived from human embryonic stem cells. Cytotherapy. 2011; 13(2):165-78. DOI: 10.3109/14653249.2010.512632. View

Shohara R, Yamamoto A, Takikawa S, Iwase A, Hibi H, Kikkawa F . Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms. Cytotherapy. 2012; 14(10):1171-81. DOI: 10.3109/14653249.2012.706705. View

Helmick C, Lee-Han H, Hirsch S, Baird T, Bartlett C . Prevalence of psoriasis among adults in the U.S.: 2003-2006 and 2009-2010 National Health and Nutrition Examination Surveys. Am J Prev Med. 2014; 47(1):37-45. PMC: 4653077. DOI: 10.1016/j.amepre.2014.02.012. View

Pawitan J . Prospect of stem cell conditioned medium in regenerative medicine. Biomed Res Int. 2014; 2014:965849. PMC: 4229962. DOI: 10.1155/2014/965849. View

10.

Lee S, Choi E, Cha M, Hwang K . Cell adhesion and long-term survival of transplanted mesenchymal stem cells: a prerequisite for cell therapy. Oxid Med Cell Longev. 2015; 2015:632902. PMC: 4333334. DOI: 10.1155/2015/632902. View

11.

Boehncke W, Schon M . Psoriasis. Lancet. 2015; 386(9997):983-94. DOI: 10.1016/S0140-6736(14)61909-7. View

12.

Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan P, Thappa D, Negi V . Investigation of association of the IL-12B and IL-23R genetic variations with psoriatic risk in a South Indian Tamil cohort. Hum Immunol. 2015; 77(1):54-62. DOI: 10.1016/j.humimm.2015.10.006. View

13.

Chen H, Niu J, Ning H, Pan X, Li X, Li Y . Treatment of Psoriasis with Mesenchymal Stem Cells. Am J Med. 2015; 129(3):e13-4. DOI: 10.1016/j.amjmed.2015.11.001. View

14.

Li M, Luan F, Zhao Y, Hao H, Liu J, Dong L . Mesenchymal stem cell-conditioned medium accelerates wound healing with fewer scars. Int Wound J. 2015; 14(1):64-73. PMC: 7949734. DOI: 10.1111/iwj.12551. View

15.

Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan P, Thappa D, Negi V . TNFAIP3 and TNIP1 polymorphisms confer psoriasis risk in South Indian Tamils. Br J Biomed Sci. 2016; 72(4):168-73. DOI: 10.1080/09674845.2015.11665748. View

16.

Mahla R . Stem Cells Applications in Regenerative Medicine and Disease Therapeutics. Int J Cell Biol. 2016; 2016:6940283. PMC: 4969512. DOI: 10.1155/2016/6940283. View

17.

Indhumathi S, Rajappa M, Chandrashekar L, Ananthanarayanan P, Thappa D, Negi V . T helper-2 cytokine/regulatory T-cell gene polymorphisms and their relation with risk of psoriasis in a South Indian Tamil cohort. Hum Immunol. 2016; 78(2):209-215. DOI: 10.1016/j.humimm.2016.12.006. View

18.

Lee Y, Sah S, Lee J, Seo K, Kang K, Kim T . Human umbilical cord blood-derived mesenchymal stem cells ameliorate psoriasis-like skin inflammation in mice. Biochem Biophys Rep. 2017; 9:281-288. PMC: 5614481. DOI: 10.1016/j.bbrep.2016.10.002. View

19.

Thappa D, Munisamy M . Research on psoriasis in India: Where do we stand?. Indian J Med Res. 2017; 146(2):147-149. PMC: 5761022. DOI: 10.4103/ijmr.IJMR_1296_17. View

20.

Comella K, Parlo M, Daly R, Dominessy K . First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study. Int Med Case Rep J. 2018; 11:59-64. PMC: 5868735. DOI: 10.2147/IMCRJ.S163612. View