A Multi-component, Family-focused and Literacy-sensitive Intervention to Improve Medication Adherence in Patients with Heart Failure-A Randomized Controlled Trial

Overview

Journal Heart Lung

Specialty Cardiology & Vascular Diseases

Date 2019 Jun 12

PMID 31182217

Citations 13

Authors

Jia-Rong Wu

Barbara Mark

George J Knafl

Sandra B Dunbar

Patricia P Chang

Darren A DeWalt

Affiliations

Soon will be listed here.

Abstract

Background: Medication nonadherence is prevalent and links to serious outcomes (e.g., rehospitalization/death) in heart failure (HF) patients; therefore, an urgent need exists for an intervention to improve and sustain adherence after intervention completion.

Objectives: To test the efficacy of a multi-component, family-focused, literacy-sensitive (FamLit) intervention on medication adherence in HF patients.

Methods: Forty-three HF patients and their care partners were enrolled and randomized to receive FamLit or attention-only intervention, including an in-person session at baseline and bi-weekly phone boosters for 3 months. We measured medication adherence from baseline to 3-month post-intervention using the Medication Event Monitoring System.

Results: After 3-month intervention, intervention patients had significantly better medication adherence than control patients. At 6 months (3-months post-intervention), intervention effect on adherence was sustained in the FamLit intervention group, while adherence decreased in the control group.

Conclusion: Incorporating care partner support and providing an easy-to-understand intervention to patients-care partners may improve/sustain adherence.

Citing Articles

Health Literacy in Heart Failure: A Review of the Gaps and Challenges.

Ionescu R, Allen L, Breathett K, Fowler B, Jackson E, Kundrick J JACC Adv. 2025; 4(3):101608.

PMID: 39951936 PMC: 11871465. DOI: 10.1016/j.jacadv.2025.101608.

Development and Testing of a Multi-Component Intervention to Improve Medication Literacy in Glaucoma Patients.

Ge W, Bian W, Wang L, Duan L, Guo J, Wang L Patient Prefer Adherence. 2024; 18:2347-2357.

PMID: 39583137 PMC: 11585269. DOI: 10.2147/PPA.S481013.

Caregivers' Contributions to Heart Failure Self-care: An Updated Systematic Review.

Buck H, Howland C, Stawnychy M, Aldossary H, Cortes Y, DeBerg J J Cardiovasc Nurs. 2024; 39(3):266-278.

PMID: 38306302 PMC: 11291720. DOI: 10.1097/JCN.0000000000001060.

Medication adherence in adults after hospitalization for heart failure: A cross-sectional study.

Huber M, Busch A, Stalder-Ochsner I, Flammer A, Schmid-Mohler G Int J Cardiol Cardiovasc Risk Prev. 2024; 20:200234.

PMID: 38299126 PMC: 10828571. DOI: 10.1016/j.ijcrp.2023.200234.

Effectiveness of cardiac rehabilitation programs on medication adherence in patients with cardiovascular disease: A systematic review and meta-analysis.

Gebremichael L, Champion S, Nesbitt K, Pearson V, Bulamu N, Dafny H Int J Cardiol Cardiovasc Risk Prev. 2024; 20:200229.

PMID: 38188637 PMC: 10770721. DOI: 10.1016/j.ijcrp.2023.200229.

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