Hepatitis E Virus Assembly and Release

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2019 Jun 12

PMID 31181848

Citations 15

Authors

Xiaohui Ju

Qiang Ding

Affiliations

Soon will be listed here.

Abstract

Hepatitis E is an underestimated threat to public health, caused by the hepatitis E virus (HEV). HEV is the most common cause of acute viral hepatitis in the world, with no available direct-acting antiviral treatment. According to a recent WHO report, 20 million people become infected with HEV annually, resulting in 44,000 deaths. However, due to the scarcity of efficient in vitro cell culture systems for HEV, our knowledge of the life cycle of HEV is incomplete. Recently, significant progress has been made towards gaining a more comprehensive view of the HEV life cycle, as several in vitro culturing systems have been developed in recent years. Here, we review current knowledge and recent advances with regard to the HEV life cycle, with a particular focus on the assembly and release of viral particles. We also discuss the knowledge gaps in HEV assembly and release. Meanwhile, we highlight experimental platforms that could potentially be utilized to fill these gaps. Lastly, we offer perspectives on the future of research into HEV virology and its interaction with host cells.

Citing Articles

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PMID: 39708671 PMC: 11729666. DOI: 10.1016/j.psj.2024.104655.

From discovery to treatment: tracing the path of hepatitis E virus.

Letafati A, Taghiabadi Z, Roushanzamir M, Memarpour B, Seyedi S, Farahani A Virol J. 2024; 21(1):194.

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Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.

Sheng Y, Deng Y, Li X, Ji P, Sun X, Liu B J Virol. 2024; 98(4):e0164923.

PMID: 38548704 PMC: 11019958. DOI: 10.1128/jvi.01649-23.

Virus-Host Protein Interaction Network of the Hepatitis E Virus ORF2-4 by Mammalian Two-Hybrid Assays.

Corneillie L, Lemmens I, Weening K, De Meyer A, Van Houtte F, Tavernier J Viruses. 2023; 15(12).

PMID: 38140653 PMC: 10748205. DOI: 10.3390/v15122412.

The PRMT5/WDR77 complex restricts hepatitis E virus replication.

Ju X, Yu Y, Ren W, Dong L, Meng X, Deng H PLoS Pathog. 2023; 19(6):e1011434.

PMID: 37276230 PMC: 10270597. DOI: 10.1371/journal.ppat.1011434.

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