Use of Nanoparticles in Tissue Engineering and Regenerative Medicine

Overview

Journal Front Bioeng Biotechnol

Date 2019 Jun 11

PMID 31179276

Citations 95

Authors

Milad Fathi-Achachelouei

Helena Knopf-Marques

Cristiane Evelise Ribeiro da Silva

Julien Barthes

Erhan Bat

Aysen Tezcaner

Nihal Engin Vrana

Affiliations

Soon will be listed here.

Abstract

Advances in nanoparticle (NP) production and demand for control over nanoscale systems have had significant impact on tissue engineering and regenerative medicine (TERM). NPs with low toxicity, contrasting agent properties, tailorable characteristics, targeted/stimuli-response delivery potential, and precise control over behavior (via external stimuli such as magnetic fields) have made it possible their use for improving engineered tissues and overcoming obstacles in TERM. Functional tissue and organ replacements require a high degree of spatial and temporal control over the biological events and also their real-time monitoring. Presentation and local delivery of bioactive (growth factors, chemokines, inhibitors, cytokines, genes etc.) and contrast agents in a controlled manner are important implements to exert control over and monitor the engineered tissues. This need resulted in utilization of NP based systems in tissue engineering scaffolds for delivery of multiple growth factors, for providing contrast for imaging and also for controlling properties of the scaffolds. Depending on the application, materials, as polymers, metals, ceramics and their different composites can be utilized for production of NPs. In this review, we will cover the use of NP systems in TERM and also provide an outlook for future potential use of such systems.

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References

Salata O . Applications of nanoparticles in biology and medicine. J Nanobiotechnology. 2004; 2(1):3. PMC: 419715. DOI: 10.1186/1477-3155-2-3. View

Vieira S, Vial S, Reis R, Oliveira J . Nanoparticles for bone tissue engineering. Biotechnol Prog. 2017; 33(3):590-611. DOI: 10.1002/btpr.2469. View

Yao C, Zhu J, Xie A, Shen Y, Li H, Zheng B . Graphene oxide and creatine phosphate disodium dual template-directed synthesis of GO/hydroxyapatite and its application in drug delivery. Mater Sci Eng C Mater Biol Appl. 2017; 73:709-715. DOI: 10.1016/j.msec.2016.11.083. View

Savla R, Minko T . Nanoparticle design considerations for molecular imaging of apoptosis: Diagnostic, prognostic, and therapeutic value. Adv Drug Deliv Rev. 2016; 113:122-140. DOI: 10.1016/j.addr.2016.06.016. View

Kunath S, Panagiotopoulou M, Maximilien J, Marchyk N, Sanger J, Haupt K . Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics. Adv Healthc Mater. 2015; 4(9):1322-6. DOI: 10.1002/adhm.201500145. View

Gupta A, Gupta M . Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials. 2005; 26(18):3995-4021. DOI: 10.1016/j.biomaterials.2004.10.012. View

Gentemann L, Kalies S, Coffee M, Meyer H, Ripken T, Heisterkamp A . Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles. Biomed Opt Express. 2017; 8(1):177-192. PMC: 5231291. DOI: 10.1364/BOE.8.000177. View

Tong W, Lu Z, Qin L, Mauck R, Smith H, Smith L . Cell therapy for the degenerating intervertebral disc. Transl Res. 2016; 181:49-58. PMC: 5776755. DOI: 10.1016/j.trsl.2016.11.008. View

Mokhena T, Luyt A . Electrospun alginate nanofibres impregnated with silver nanoparticles: Preparation, morphology and antibacterial properties. Carbohydr Polym. 2017; 165:304-312. DOI: 10.1016/j.carbpol.2017.02.068. View

10.

Ghanbari Mehrabani M, Karimian R, Mehramouz B, Rahimi M, Kafil H . Preparation of biocompatible and biodegradable silk fibroin/chitin/silver nanoparticles 3D scaffolds as a bandage for antimicrobial wound dressing. Int J Biol Macromol. 2018; 114:961-971. DOI: 10.1016/j.ijbiomac.2018.03.128. View

11.

Vrana N, Erdemli O, Francius G, Fahs A, Rabineau M, Debry C . Double entrapment of growth factors by nanoparticles loaded into polyelectrolyte multilayer films. J Mater Chem B. 2020; 2(8):999-1008. DOI: 10.1039/c3tb21304h. View

12.

Gao G, Schilling A, Yonezawa T, Wang J, Dai G, Cui X . Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells. Biotechnol J. 2014; 9(10):1304-11. DOI: 10.1002/biot.201400305. View

13.

Zuidema J, Provenza C, Caliendo T, Dutz S, Gilbert R . Magnetic NGF-releasing PLLA/iron oxide nanoparticles direct extending neurites and preferentially guide neurites along aligned electrospun microfibers. ACS Chem Neurosci. 2015; 6(11):1781-8. DOI: 10.1021/acschemneuro.5b00189. View

14.

Chang Y, Chen M, Liao S, Wu H, Kuan C, Sun J . Multichanneled Nerve Guidance Conduit with Spatial Gradients of Neurotrophic Factors and Oriented Nanotopography for Repairing the Peripheral Nervous System. ACS Appl Mater Interfaces. 2017; 9(43):37623-37636. DOI: 10.1021/acsami.7b12567. View

15.

Amoli-Diva M, Sadighi-Bonabi R, Pourghazi K . Switchable on/off drug release from gold nanoparticles-grafted dual light- and temperature-responsive hydrogel for controlled drug delivery. Mater Sci Eng C Mater Biol Appl. 2017; 76:242-248. DOI: 10.1016/j.msec.2017.03.038. View

16.

Zamproni L, Mundim M, Porcionatto M, des Rieux A . Injection of SDF-1 loaded nanoparticles following traumatic brain injury stimulates neural stem cell recruitment. Int J Pharm. 2017; 519(1-2):323-331. DOI: 10.1016/j.ijpharm.2017.01.036. View

17.

Mohandas A, Anisha B, Chennazhi K, Jayakumar R . Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds. Colloids Surf B Biointerfaces. 2015; 127:105-13. DOI: 10.1016/j.colsurfb.2015.01.024. View

18.

Hudson D, Margaritis A . Biopolymer nanoparticle production for controlled release of biopharmaceuticals. Crit Rev Biotechnol. 2013; 34(2):161-79. DOI: 10.3109/07388551.2012.743503. View

19.

Bhowmick S, Koul V . Assessment of PVA/silver nanocomposite hydrogel patch as antimicrobial dressing scaffold: Synthesis, characterization and biological evaluation. Mater Sci Eng C Mater Biol Appl. 2015; 59:109-119. DOI: 10.1016/j.msec.2015.10.003. View

20.

Gao M, Chen J, Lin G, Li S, Wang L, Qin A . Long-Term Tracking of the Osteogenic Differentiation of Mouse BMSCs by Aggregation-Induced Emission Nanoparticles. ACS Appl Mater Interfaces. 2016; 8(28):17878-84. DOI: 10.1021/acsami.6b05471. View