Microbicidal Phagocytosis of Nucleus Pulposus Cells Against Via the TLR2/MAPKs Signaling Pathway

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Jun 11

PMID 31178866

Citations 5

Authors

YaZhou Lin

Hui Cong

Kewei Liu

Yucheng Jiao

Ye Yuan

Guoqing Tang

Yong Chen

Yuehuan Zheng

Jiaqi Xiao

Changwei Li

Zhe Chen

Peng Cao

Affiliations

Soon will be listed here.

Abstract

Intervertebral disc (IVD) is an immune-privileged organ that lacks immunocytes, such as macrophages or neutrophils; therefore, it is unclear how IVD immunological defense against bacterial infection occurs. Here, we demonstrated that nucleus pulposus cells (NPCs), the vital machinery for maintaining the homeostasis of IVD, exerted microbicidal activity against via induction of phagolysosome formation. Moreover, we found that the Toll-like receptor 2 (TLR2)/mitogen-activated protein kinases (MAPKs) signaling pathway is critical for bacterial phagocytosis and phagolysosome formation of NPCs. These findings demonstrated for the first time that NPCs could function as non-professional phagocytes against infection, thereby enhancing antimicrobial defense against bacterial infections in IVDs.

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