LINC00311 is Overexpressed in Ankylosing Spondylitis and Predict Treatment Outcomes and Recurrence

Overview

Journal BMC Musculoskelet Disord

Publisher Biomed Central

Specialties Orthopedics
Physiology

Date 2019 Jun 8

PMID 31170957

Citations 13

Authors

Hongfa Zhong

Mingliang Zhong

Affiliations

Soon will be listed here.

Abstract

Background: LncRNA LINC00311 participates in osteoporosis, which shows inverse pathological changes to ankylosing spondylitis (AS), indicating that LINC00311 is also involved in AS.

Methods: All the participants were enrolled in Ganzhou People's Hospital between January 2016 and January 2018 after this study was approved by Ganzhou People's Hospital Ethics Committee. Disease activity determination, follow-up and RT-qPCR were carried out during the research.

Results: In the present study we found that LINC00311 was upregulated in AS patients comparing to healthy controls, and upregulation of LINC00311 distinguished AS patients from healthy controls. LINC00311 expression levels were positively correlated with disease activity. Comparing to pre-treatment levels, LINC00311 expression level decreased significantly after treatment. During 2-year follow-up, patients with high levels of LINC00311 showed a significantly higher rate of rehospitalization.

Conclusions: Therefore, LINC00311 is overexpressed in AS and predict treatment outcomes and recurrence.

Citing Articles

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PMID: 39082011 PMC: 11284430. DOI: 10.1016/j.heliyon.2024.e34634.

A review of long non-coding RNAs in ankylosing spondylitis: pathogenesis, clinical assessment, and therapeutic targets.

Wang H, Yang C, Li G, Wang B, Qi L, Wang Y Front Cell Dev Biol. 2024; 12:1362476.

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Triptolide alleviates the development of inflammation in ankylosing spondylitis via the NONHSAT227927.1/JAK2/STAT3 pathway.

Ding X, Liu J, Sun Y, Chen X Exp Ther Med. 2024; 27(1):17.

PMID: 38223328 PMC: 10785042. DOI: 10.3892/etm.2023.12305.

LncRNA HOTTIP impacts the proliferation and differentiation of fibroblast-like synoviocytes in ankylosing spondylitis through the microRNA-30b-3p/PGK1 axis.

Wei L, Zhang X, Yao Y, Zheng W, Tian J J Orthop Surg Res. 2023; 18(1):237.

PMID: 36964567 PMC: 10039568. DOI: 10.1186/s13018-023-03653-4.

Novel regulatory role of non-coding RNAs in ankylosing spondylitis.

Fang Y, Liu J Front Immunol. 2023; 14:1131355.

PMID: 36911689 PMC: 9998703. DOI: 10.3389/fimmu.2023.1131355.

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