Recurrent Stroke and Multi-infarct Dementia in Systemic Lupus Erythematosus: Association with Antiphospholipid Antibodies

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1987 Aug 1

PMID 3116954

Citations 31

Authors

R A Asherson

D Mercey

G Phillips

N Sheehan

A E Gharavi

E N Harris

G R Hughes

Affiliations

Soon will be listed here.

Abstract

Four patients with recurrent stroke and multi-infarct dementia are presented in whom the dementia was progressive and severe. Three of the patients developed the dementia during the course of an illness which was punctuated by repeated episodes of cerebral infarction demonstrated by computed tomographic (CT) scans. The fourth patient presented with an illness dominated by progressive and deteriorating higher mental functions, which culminated in a major stroke 18 months later. Three patients fulfilled the American Rheumatism Association (ARA) criteria for the classification of systemic lupus erythematosus, the fourth had a 'lupus-like' disease. All had livedo reticularis, severe migraines, and also demonstrated antibodies to phospholipids. All four patients suffered deep vein thromboses.

Citing Articles

Presence of Extra-Criteria Antiphospholipid Antibodies Is an Independent Risk Factor for Ischemic Stroke.

Naranjo L, Ostos F, Gil-Etayo F, Hernandez-Gallego J, Cabrera-Marante O, Pleguezuelo D Front Cardiovasc Med. 2021; 8:665741.

PMID: 34012984 PMC: 8126615. DOI: 10.3389/fcvm.2021.665741.

Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis.

Islam M, Alam F, Kamal M, Gan S, Sasongko T, Wong K Front Aging Neurosci. 2017; 9:250.

PMID: 28824414 PMC: 5539075. DOI: 10.3389/fnagi.2017.00250.

Antiphospholipid syndrome (APS) revisited: Would migraine headaches be included in future classification criteria?.

Noureldine M, Haydar A, Berjawi A, Elnawar R, Sweid A, Khamashta M Immunol Res. 2016; 65(1):230-241.

PMID: 27423434 DOI: 10.1007/s12026-016-8831-9.

Revisiting the molecular mechanism of neurological manifestations in antiphospholipid syndrome: beyond vascular damage.

Carecchio M, Cantello R, Comi C J Immunol Res. 2014; 2014:239398.

PMID: 24741580 PMC: 3987798. DOI: 10.1155/2014/239398.

Brain MR findings in patients with systemic lupus erythematosus with and without antiphospholipid antibody syndrome.

Kaichi Y, Kakeda S, Moriya J, Ohnari N, Saito K, Tanaka Y AJNR Am J Neuroradiol. 2013; 35(1):100-5.

PMID: 23886740 PMC: 7966497. DOI: 10.3174/ajnr.A3645.

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