The Ex Vivo Human Lung: Research Value for Translational Science

Overview

Journal JCI Insight

Specialties Biomedical Engineering
General Medicine

Date 2019 Jun 7

PMID 31167972

Citations 18

Authors

James T Ross

Nicolas Nesseler

Jae-Woo Lee

Lorraine B Ware

Michael A Matthay

Affiliations

Soon will be listed here.

Abstract

Respiratory diseases are among the leading causes of death and disability worldwide. However, the pathogenesis of both acute and chronic lung diseases remains incompletely understood. As a result, therapeutic options for important clinical problems, including acute respiratory distress syndrome and chronic obstructive pulmonary disease, are limited. Research efforts have been held back in part by the difficulty of modeling lung injury in animals. Donor human lungs that have been rejected for transplantation offer a valuable alternative for understanding these diseases. In 2007, our group developed a simple preparation of an ex vivo-perfused single human lung. In this Review, we discuss the availability of donor human lungs for research, describe the ex vivo-perfused lung preparation, and highlight how this preparation can be used to study the mechanisms of lung injury, to isolate primary cells, and to test novel therapeutics.

Citing Articles

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Feasibility and accuracy of DireCt Lung Ultrasound Evaluation technique to monitor extravascular lung water in porcine lungs.

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A meta-analysis of perfusion parameters affecting weight gain in ex vivo perfusion.

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Cell-Free Hemoglobin in the Pathophysiology of Trauma: A Scoping Review.

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Perioperative fluid management for lung transplantation is challenging.

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