IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT

Overview

Journal Rev Paul Pediatr

Specialty Pediatrics

Date 2019 Jun 6

PMID 31166468

Citations 6

Authors

Sofia Alexandra Pereira Pires

Ana Pereira Lemos

Ester Preciosa Maio Nunes Pereira

Paulo Alexandre da Silva Vilar Maia

Joao Patricio de Sousa E Alvim Bismarck do Agro

Affiliations

Soon will be listed here.

Abstract

Objective: To report a case of a male adolescent with the diagnosis of ibuprofen-induced meningitis. We discuss themain causes of drug-induced aseptic meningitis (DIAM) and highlight the importance of early recognition of DIAM, sothat the offending drug can be withdrawn, and recurrences prevented. Only few DIAM cases have been reported in pediatric age.

Case Description: A healthy 15-year-old boy presented to the emergency department with headache, nausea, dizziness, fever, conjunctival hyperemia and blurred vision 30 minutes after ibuprofen-intake. During his stay, he developed emesis and neck stiffness. Cerebrospinal ﬂuid analysis excluded infectious causes, and DIAM was considered. He totally recovered after drug withdrawal.

Comments: DIAM is a rare entity, that should be considered in the differential diagnosis of an aseptic meningitis. The major causative agents are nonsteroidal anti-inflammatory drugs, particularly ibuprofen. Suspicion is made by the chronologic link between drug intake and the beginning of symptoms, but infectious causes should always be ruled out.

Citing Articles

A Dilemma in the Diagnosis of Group A Streptococcus (GAS) Meningitis Versus Drug-Induced Aseptic Meningitis: A Case Report.

Sharma R, Jaafar N, Guru N, Oh E, Guru S Cureus. 2025; 17(2):e79443.

PMID: 39995590 PMC: 11848696. DOI: 10.7759/cureus.79443.

Ibuprofen: The Hidden Culprit Behind Aseptic Meningitis.

Kalfoutzou A, Petroulakis P, Tsiouri E, Fafoutis T, Mylonakis A, Dimitrakoudi M Cureus. 2024; 16(8):e65936.

PMID: 39221408 PMC: 11365196. DOI: 10.7759/cureus.65936.

A Case of Ketorolac-Induced Aseptic Meningitis.

Shahin L, Rogers A, Swain L, Ourn F, Barber T Cureus. 2024; 16(3):e57349.

PMID: 38690497 PMC: 11060875. DOI: 10.7759/cureus.57349.

Elderly Woman With No Autoimmune Disease With Aseptic Meningitis Caused by Celecoxib.

Takigawa M, Tanaka H, Kobayashi T, Katahara Y, Kinoshita M, Masuda M Cureus. 2024; 16(3):e55348.

PMID: 38559550 PMC: 10981950. DOI: 10.7759/cureus.55348.

Aseptic Meningitis Secondary to Antibiotic Therapy.

Negron-Diaz J, Klumpp L, Mayer C, Jordan J Cureus. 2021; 13(4):e14454.

PMID: 33996314 PMC: 8117791. DOI: 10.7759/cureus.14454.

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