Distinguishing Logopenic from Semantic & Nonfluent Variant Primary Progressive Aphasia: Patterns of Linguistic and Behavioral Correlations

Overview

Journal Neurocase

Publisher Routledge

Specialties Neurology
Psychiatry
Psychology
Social Sciences

Date 2019 Jun 6

PMID 31164050

Citations 6

Authors

Lynsey M Keator

Amy E Wright

Sadhvi Saxena

Kevin Kim

Cornelia Demsky

Rajani Sebastian

Shannon M Sheppard

Bonnie Breining

Argye E Hillis

Donna C Tippett

Affiliations

Soon will be listed here.

Abstract

While language characteristics of logopenic variant primary progressive aphasia (lvPPA) are well-defined, behavioral characteristics are less understood. We investigated correlations between language and behavioral scores across three variants of primary progressive aphasia (PPA) and found language performance and behavioral disturbances are correlated in lvPPA, but not other PPA subtypes. Results suggest that unlike other PPA variants, patients diagnosed with lvPPA do not develop negative behaviors until language deficits are severe. This is consistent with the underlying neuropathology of lvPPA, Alzheimer's Disease. Such findings are crucial to clinical prognosis, especially when considering the progressive nature of this disease.

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Clinical and neuroimaging characteristics of primary progressive aphasia.

Tippett D, Keser Z Handb Clin Neurol. 2022; 185:81-97.

PMID: 35078612 PMC: 9951770. DOI: 10.1016/B978-0-12-823384-9.00016-5.

Ethical and Practical Challenges of the Communication and Behavioral Manifestations of Primary Progressive Aphasia.

Tippett D, Hillis A Semin Speech Lang. 2020; 41(3):249-256.

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