Secondary Squamous Cell Carcinoma of the Oral Cavity After Nasopharyngeal Carcinoma

Overview

Journal Cancer Res Treat

Specialty Oncology

Date 2019 Jun 6

PMID 31163959

Citations 12

Authors

Liyuan Dai

Qigen Fang

Peng Li

Junfu Wu

Xu Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design.

Materials And Methods: Records of patients with surgically treated primary oral SCC were reviewed, and a total of 83 patients with previous history of radiotherapy for nasopharyngeal carcinoma (NPC) were retrospectively enrolled. A matched-pair study was performed, each NPC survivor was matched with two sporadic oral SCC patients by age, sex, primary tumor site, adverse pathologic characteristics, disease stage, neck node status, and tumor stage. The overall survival (OS) and disease-specific survival (DSS) rates were calculated by the Kaplan-Meier method; independent prognostic factors were evaluated by the Cox proportional hazards method.

Results: Compared with sporadic oral SCC patients, NPC survivors were less likely to be smokers (p=0.004), perineural invasion and lymphovascular invasion were more common in NPC survivors (both p < 0.001). The 5-year OS and DSS rates in NPC survivors were 47% and 54%, respectively; the 5-year OS and DSS rates in sporadic oral SCC patients were 62% and 67%, respectively; the difference was significant (both p < 0.05). In survival analysis, disease stage remained to be independent prognostic factor for both the OS and DSS.

Conclusion: NPC survivors had worse OS and DSS than sporadic oral SCC patients, NPC survivors were less likely to be smokers, but had higher opportunity of perineural invasion and lymphovascular invasion. Disease stage was the most important predictor for the survival in NPC survivors.

Citing Articles

Impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma.

Wang Q, Huang T, Wei X PLoS One. 2024; 19(10):e0311094.

PMID: 39413080 PMC: 11482683. DOI: 10.1371/journal.pone.0311094.

Oral Squamous Cell Carcinoma and Concomitant Primary Tumors, What Do We Know? A Review of the Literature.

Badwelan M, Muaddi H, Ahmed A, Lee K, Tran S Curr Oncol. 2023; 30(4):3721-3734.

PMID: 37185396 PMC: 10136780. DOI: 10.3390/curroncol30040283.

Secondary primary tumor mimicking osteoradionecrosis.

Carvalho G, Heguedusch D, Pellizzon A, Lira R, Alves F, Jaguar G Autops Case Rep. 2022; 12:e2021389.

PMID: 36061099 PMC: 9352367. DOI: 10.4322/acr.2021.389.

Secondary Oral Cancer after Systemic Treatment of Hematological Malignancies and Oral GVHD: A Systematic Review.

Janowiak-Majeranowska A, Osowski J, Mikaszewski B, Majeranowski A Cancers (Basel). 2022; 14(9).

PMID: 35565303 PMC: 9102759. DOI: 10.3390/cancers14092175.

Orocutaneous Fistula Formation in Free Flap Reconstruction for Oral Squamous Cell Carcinoma.

Fang Q, Yuan J, Du W, Dai L, Zhang X, Luo R Front Oncol. 2022; 12:887118.

PMID: 35558508 PMC: 9086589. DOI: 10.3389/fonc.2022.887118.

References

Zhang P, Zhang L, Liu H, Zhao L, Li Y, Shen J . Clinicopathologic Characteristics and Prognosis of Tongue Squamous Cell Carcinoma in Patients with and without a History of Radiation for Nasopharyngeal Carcinoma: A Matched Case-Control Study. Cancer Res Treat. 2016; 49(3):695-705. PMC: 5512375. DOI: 10.4143/crt.2016.317. View

Fang Q, Li P, Qi J, Luo R, Chen D, Zhang X . Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. Laryngoscope. 2019; 129(11):2527-2530. DOI: 10.1002/lary.27927. View

Fang Q, Shi S, Liu F, Sun C . Squamous cell carcinoma of the oral cavity in ever smokers: a matched-pair analysis of survival. J Craniofac Surg. 2014; 25(3):934-7. DOI: 10.1097/SCS.0000000000000710. View

Tubiana M . Can we reduce the incidence of second primary malignancies occurring after radiotherapy? A critical review. Radiother Oncol. 2009; 91(1):4-15. DOI: 10.1016/j.radonc.2008.12.016. View

Chen S, Zhang Q, Guo Z, Chen W, Liu W, Chen Y . Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution. Cancer Manag Res. 2018; 10:4523-4535. PMC: 6190823. DOI: 10.2147/CMAR.S171251. View

Broeks A, Braaf L, Wessels L, Van de Vijver M, De Bruin M, Stovall M . Radiation-associated breast tumors display a distinct gene expression profile. Int J Radiat Oncol Biol Phys. 2010; 76(2):540-7. DOI: 10.1016/j.ijrobp.2009.09.004. View

Chen M, Feng I, Lu C, Chen C, Lin J, Huang S . The incidence and risk of second primary cancers in patients with nasopharyngeal carcinoma: a population-based study in Taiwan over a 25-year period (1979-2003). Ann Oncol. 2008; 19(6):1180-6. DOI: 10.1093/annonc/mdn003. View

Diallo I, Haddy N, Adjadj E, Samand A, Quiniou E, Chavaudra J . Frequency distribution of second solid cancer locations in relation to the irradiated volume among 115 patients treated for childhood cancer. Int J Radiat Oncol Biol Phys. 2009; 74(3):876-83. DOI: 10.1016/j.ijrobp.2009.01.040. View

Sun C, Hu Z, Zhong Z, Jiang Y, Sun R, Fei J . Clinical and prognostic analysis of second primary squamous cell carcinoma of the tongue after radiotherapy for nasopharyngeal carcinoma. Br J Oral Maxillofac Surg. 2014; 52(8):715-20. DOI: 10.1016/j.bjoms.2014.06.015. View

10.

Kong L, Lu J, Hu C, Guo X, Wu Y, Zhang Y . The risk of second primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy. Cancer. 2006; 107(6):1287-93. DOI: 10.1002/cncr.22119. View

11.

Bachar G, Hod R, Goldstein D, Irish J, Gullane P, Brown D . Outcome of oral tongue squamous cell carcinoma in patients with and without known risk factors. Oral Oncol. 2010; 47(1):45-50. DOI: 10.1016/j.oraloncology.2010.11.003. View

12.

Chatzistefanou I, Lubek J, Markou K, Ord R . The role of perineural invasion in treatment decisions for oral cancer patients: A review of the literature. J Craniomaxillofac Surg. 2017; 45(6):821-825. DOI: 10.1016/j.jcms.2017.02.022. View

13.

Oei R, Ye L, Kong F, Du C, Zhai R, Xu T . Prognostic value of inflammation-based prognostic index in patients with nasopharyngeal carcinoma: a propensity score matching study. Cancer Manag Res. 2018; 10:2785-2797. PMC: 6103307. DOI: 10.2147/CMAR.S171239. View

14.

Arlen M, HIGINBOTHAM N, Huvos A, Marcove R, Miller T, Shah I . Radiation-induced sarcoma of bone. Cancer. 1971; 28(5):1087-99. DOI: 10.1002/1097-0142(1971)28:5<1087::aid-cncr2820280502>3.0.co;2-f. View

15.

Teo P, Chan A, Leung S, Chau R, Yu P, King W . Increased incidence of tongue cancer after primary radiotherapy for nasopharyngeal carcinoma--the possibility of radiation carcinogenesis. Eur J Cancer. 1999; 35(2):219-25. DOI: 10.1016/s0959-8049(98)00386-4. View

16.

Sahu V, Nigam L, Agnihotri V, Gupta A, Shekhar S, Subbarao N . Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same. Cancer Res Treat. 2018; 51(1):313-325. PMC: 6333999. DOI: 10.4143/crt.2018.105. View

17.

Bostrom P, Soloway M . Secondary cancer after radiotherapy for prostate cancer: should we be more aware of the risk?. Eur Urol. 2007; 52(4):973-82. DOI: 10.1016/j.eururo.2007.07.002. View

18.

Fang Q, Shi S, Li M, Zhang X, Liu F, Sun C . Free flap reconstruction versus non-free flap reconstruction in treating elderly patients with advanced oral cancer. J Oral Maxillofac Surg. 2014; 72(7):1420-4. DOI: 10.1016/j.joms.2014.01.010. View

19.

Ng A, Bernardo M, Weller E, Backstrand K, Silver B, Marcus K . Long-term survival and competing causes of death in patients with early-stage Hodgkin's disease treated at age 50 or younger. J Clin Oncol. 2002; 20(8):2101-8. DOI: 10.1200/JCO.2002.08.021. View

20.

Zhao W, Lei H, Zhu X, Li L, Qu S, Liang X . The clinical characteristics of secondary primary tumors in patients with nasopharyngeal carcinoma after intensity-modulated radiotherapy: A retrospective analysis. Medicine (Baltimore). 2016; 95(45):e5364. PMC: 5106069. DOI: 10.1097/MD.0000000000005364. View