Developing a Crosswalk Between the RAND-12 and the Health Utilities Index for Multiple Sclerosis

Overview

Journal Mult Scler

Publisher Sage Publications

Specialty Neurology

Date 2019 Jun 5

PMID 31161917

Citations 4

Authors

Ruth Ann Marrie

Brenden Dufault

Tuula Tyry

Gary R Cutter

Robert J Fox

Amber Salter

Affiliations

Soon will be listed here.

Abstract

Background: Researchers studying health-related quality of life (HRQOL) in multiple sclerosis (MS) can choose from many instruments, but findings from studies which use different instruments cannot be easily combined. We aimed to develop a crosswalk that associates scores from the RAND-12 to scores on the Health Utilities Index-Mark III (HUI3) in persons with MS.

Methods: In 2018, participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) registry completed the RAND-12 and the HUI3 to assess HRQOL. We used item-response theory (IRT) and equipercentile linking approaches to develop a crosswalk between instruments. We compared predicted scores for the HUI3 from each crosswalk to observed scores using Pearson correlations, intraclass correlation coefficients (ICCs), and Bland-Altman plots.

Results: Of 11,389 invited participants, 7129 (62.6%) responded. Predicted and observed values of the HUI3 from the IRT-linking method were moderately correlated (Pearson = 0.76) with good concordance (ICC = 0.72). However, the Bland-Altman plots suggested biased prediction. Predicted and observed values from the equipercentile linking method were also moderately correlated (Pearson = 0.78, ICC = 0.78). The Bland-Altman plots suggested no bias.

Conclusion: We developed a crosswalk between the RAND-12 and the HUI3 in the MS population which will facilitate data harmonization efforts.

Citing Articles

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Comparison of the EQ-5D-5L and the patient-reported outcomes measurement information system preference score (PROPr) in the United States.

Hays R, Edelen M, Rodriguez A, Qureshi N, Feeny D, Herman P J Patient Rep Outcomes. 2024; 8(1):76.

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Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma.

Budde A, Baust K, Weinhold L, Bernstein M, Bielack S, Dhooge C Eur J Cancer. 2022; 170:209-235.

PMID: 35689897 PMC: 9251607. DOI: 10.1016/j.ejca.2022.03.018.

NARCOMS and Other Registries in Multiple Sclerosis: Issues and Insights.

Marrie R, Cutter G, Fox R, Vollmer T, Tyry T, Salter A Int J MS Care. 2022; 23(6):276-284.

PMID: 35035299 PMC: 8745235. DOI: 10.7224/1537-2073.2020-133.

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