Vitamin D and Otitis Media

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2019 Jun 5

PMID 31161313

Citations 2

Authors

Rebecca E Walker

Jim Bartley

Carlos A Camargo Jr

Edwin A Mitchell

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: To examine the relationship between vitamin D and otitis media.

Recent Findings: Vitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria. This review will explore risk factors of both otitis media and vitamin D deficiency, the evidence of vitamin D being beneficial for various forms of otitis media, and possible mechanisms of action.

Citing Articles

Perspective: School Meal Programs Require Higher Vitamin D Fortification Levels in Milk Products and Plant-Based Alternatives-Evidence from the National Health and Nutrition Examination Surveys (NHANES 2001-2018).

Calvo M, Whiting S Adv Nutr. 2022; 13(5):1440-1449.

PMID: 35671093 PMC: 9526833. DOI: 10.1093/advances/nmac068.

Panel 4: Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures.

Marsh R, Aho C, Beissbarth J, Bialasiewicz S, Binks M, Cervin A Int J Pediatr Otorhinolaryngol. 2019; 130 Suppl 1:109836.

PMID: 31879084 PMC: 7085411. DOI: 10.1016/j.ijporl.2019.109836.

References

Schappert S . Office visits for otitis media: United States, 1975-90. Adv Data. 1992; (214):1-19. View

Finkelstein J, Metlay J, Davis R, Rifas-Shiman S, Dowell S, Platt R . Antimicrobial use in defined populations of infants and young children. Arch Pediatr Adolesc Med. 2000; 154(4):395-400. DOI: 10.1001/archpedi.154.4.395. View

Lin J, Haruta A, Kawano H, Ho S, Adams G, Juhn S . Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media. J Infect Dis. 2000; 182(3):882-7. DOI: 10.1086/315767. View

Dewey C, Midgeley E, Maw R . The relationship between otitis media with effusion and contact with other children in a british cohort studied from 8 months to 3 1/2 years. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Int J Pediatr Otorhinolaryngol. 2000; 55(1):33-45. DOI: 10.1016/s0165-5876(00)00377-3. View

Wright E, Hurst D, Miotto D, Giguere C, Hamid Q . Increased expression of major basic protein (MBP) and interleukin-5(IL-5) in middle ear biopsy specimens from atopic patients with persistent otitis media with effusion. Otolaryngol Head Neck Surg. 2000; 123(5):533-8. DOI: 10.1067/mhn.2000.109472. View

Smirnova M, Birchall J, Pearson J . In vitro study of IL-8 and goblet cells: possible role of IL-8 in the aetiology of otitis media with effusion. Acta Otolaryngol. 2002; 122(2):146-52. DOI: 10.1080/00016480252814144. View

Caye-Thomasen P, Tos M . Histopathologic differences due to bacterial species in acute otitis media. Int J Pediatr Otorhinolaryngol. 2002; 63(2):99-110. DOI: 10.1016/s0165-5876(01)00641-3. View

Gates G, Klein J, Lim D, Mogi G, Ogra P, Pararella M . Recent advances in otitis media. 1. Definitions, terminology, and classification of otitis media. Ann Otol Rhinol Laryngol Suppl. 2002; 188:8-18. DOI: 10.1177/00034894021110s304. View

Jang C, Kim Y . Characterization of cytokines present in pediatric otitis media with effusion: comparison of allergy positive and negative. Int J Pediatr Otorhinolaryngol. 2002; 66(1):37-40. DOI: 10.1016/s0165-5876(02)00185-4. View

10.

. Diagnosis and management of acute otitis media. Pediatrics. 2004; 113(5):1451-65. DOI: 10.1542/peds.113.5.1451. View

11.

Lee H, Andalibi A, Webster P, Moon S, Teufert K, Kang S . Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae. BMC Infect Dis. 2004; 4:12. PMC: 428576. DOI: 10.1186/1471-2334-4-12. View

12.

Zhu Y, Mahon B, Froicu M, Cantorna M . Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol. 2004; 35(1):217-24. DOI: 10.1002/eji.200425491. View

13.

Verhoeff M, van der Veen E, Rovers M, Sanders E, Schilder A . Chronic suppurative otitis media: a review. Int J Pediatr Otorhinolaryngol. 2005; 70(1):1-12. DOI: 10.1016/j.ijporl.2005.08.021. View

14.

Slinger R, Chan F, Ferris W, Yeung S, St Denis M, Gaboury I . Multiple combination antibiotic susceptibility testing of nontypeable Haemophilus influenzae biofilms. Diagn Microbiol Infect Dis. 2006; 56(3):247-53. DOI: 10.1016/j.diagmicrobio.2006.04.012. View

15.

Hall-Stoodley L, Hu F, Gieseke A, Nistico L, Nguyen D, Hayes J . Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis media. JAMA. 2006; 296(2):202-11. PMC: 1885379. DOI: 10.1001/jama.296.2.202. View

16.

Felgentreff K, Beisswenger C, Griese M, Gulder T, Bringmann G, Bals R . The antimicrobial peptide cathelicidin interacts with airway mucus. Peptides. 2006; 27(12):3100-6. DOI: 10.1016/j.peptides.2006.07.018. View

17.

McGillivary G, Ray W, Bevins C, Munson Jr R, Bakaletz L . A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Mol Immunol. 2006; 44(9):2446-58. PMC: 1817667. DOI: 10.1016/j.molimm.2006.10.008. View

18.

Liu P, Stenger S, Tang D, Modlin R . Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007; 179(4):2060-3. DOI: 10.4049/jimmunol.179.4.2060. View

19.

Gunasekera H, Knox S, Morris P, Britt H, McIntyre P, Craig J . The spectrum and management of otitis media in Australian indigenous and nonindigenous children: a national study. Pediatr Infect Dis J. 2007; 26(8):689-92. DOI: 10.1097/INF.0b013e3180621177. View

20.

Yeo S, Park D, Hong S, Cha C, Kim M . Bacteriology of chronic suppurative otitis media--a multicenter study. Acta Otolaryngol. 2007; 127(10):1062-7. DOI: 10.1080/00016480601126978. View