Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide Through Inhibition of the EIF-2-ATF4 Pathway in Mouse Microglia

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Jun 5

PMID 31159306

Citations 30

Authors

Takayuki Inoue

Hajime Yamakage

Masashi Tanaka

Toru Kusakabe

Akira Shimatsu

Noriko Satoh-Asahara

Affiliations

Soon will be listed here.

Abstract

Microglia maintain brain homeostasis and modulate neuroinflammation and are implicated in the pathogenesis of various neurological diseases such as Alzheimer's disease. In this study, we found that in lipopolysaccharide (LPS)-stimulated microglia, the endoplasmic reticulum (ER) stress-related eIF-2-ATF4 pathway plays significant roles in TNF- and IL-6 production, as well as in the inflammasome-mediated production of IL-1. Furthermore, our analysis revealed that oxytocin (OT), a nonapeptide synthesized in the hypothalamus, suppressed the production of these proinflammatory cytokines by inhibiting activation of the eIF-2-ATF4 pathway. Our findings therefore suggest a novel anti-inflammatory axis of OT in activated microglia, which would be helpful for developing the novel effective strategies for regulating microglia-associated neuroinflammation.

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