Isoniazid and Ethambutol As a Cause of Optic Neuropathy

Overview

Journal Eur J Respir Dis

Specialty Pulmonary Medicine

Date 1987 Jul 1

PMID 3115809

Citations 6

Authors

V E Jimenez-Lucho

R del Busto

J Odel

Affiliations

Soon will be listed here.

Abstract

A well-recognized complication of ethambutol use is optic neuropathy, but the potential ocular toxicity of isoniazid is often overlooked. A patient developed optic neuropathy while being treated with isoniazid and ethambutol. The optic neuropathy subsided only when both drugs were discontinued, suggesting an additive toxic effect.

Citing Articles

Risk Factors of Optic Neuropathy in Ethambutol Users: Interaction with Isoniazid and Other Associated Conditions of Toxic Optic Neuropathy.

Kim J, Ahn S Toxics. 2024; 12(8).

PMID: 39195651 PMC: 11359443. DOI: 10.3390/toxics12080549.

Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series.

Antaki F, Javidi S, Touma S, Aubin M Clin Ophthalmol. 2020; 14:3075-3096.

PMID: 33116360 PMC: 7548324. DOI: 10.2147/OPTH.S265521.

Towards EMIC rational design: setting the molecular simulation toolbox for enantiopure molecularly imprinted catalysts.

Jalink T, Farrand T, Herdes C Chem Cent J. 2016; 10:66.

PMID: 27822298 PMC: 5078882. DOI: 10.1186/s13065-016-0215-7.

Diplopia and strabismus convergens mimicking symptoms of tuberculous meningitis as side-effects of isoniazid.

Dompeling E, Schut E, Vles H, Kooyman M, Jobsis Q, Hendriks H Eur J Pediatr. 2004; 163(8):503-4.

PMID: 15168111 DOI: 10.1007/s00431-004-1470-5.

[Severe course and contingent risk factors in optic neuropathy and myelopathy after tuberculostatics].

Frisch I, Kunze A, Castro A, Krastel H, Meinck H Ophthalmologe. 2003; 100(11):967-70.

PMID: 14669033 DOI: 10.1007/s00347-003-0823-1.