Pharmacological Effects of Gallic Acid in Health and Diseases: A Mechanistic Review

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2019 Jun 4

PMID 31156781

Citations 188

Authors

Niloofar Kahkeshani

Fatemeh Farzaei

Maryam Fotouhi

Seyedeh Shaghayegh Alavi

Roodabeh Bahramsoltani

Rozita Naseri

Saeideh Momtaz

Zahra Abbasabadi

Roja Rahimi

Mohammad Hosein Farzaei

Anupam Bishayee

Affiliations

Soon will be listed here.

Abstract

Objectives: Gallic acid is a natural phenolic compound found in several fruits and medicinal plants. It is reported to have several health-promoting effects. This review aims to summarize the pharmacological and biological activities of gallic acid and animal models to depict the pharmacological status of this compound for future studies.

Materials And Methods: All relevant papers in the English language were collected up to June 2018. The keywords of gallic acid, antioxidant, anticancer, antimicrobial, gastrointestinal-, cardiovascular-, metabolic-, neuropsychological-, and miscellaneous- diseases were searched in Google Scholar, PubMed, and Scopus.

Results: Several beneficial effects are reported for gallic acid, including antioxidant, anti-inflammatory, and antineoplastic properties. This compound has been reported to have therapeutic activities in gastrointestinal, neuropsychological, metabolic, and cardiovascular disorders.

Conclusion: Current evidence confirms the pharmacological and therapeutic interventions of gallic acid in multiple health complications; however, available data are limited to just cellular and animal studies. Future investigations are essential to further define the safety and therapeutic efficacy of gallic acid in humans.

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