The Extrinsic Risk and Its Association with Neural Alterations in Spasmodic Dysphonia

Overview

Journal Parkinsonism Relat Disord

Specialty Neurology

Date 2019 Jun 3

PMID 31153765

Citations 15

Authors

Laura de Lima Xavier

Kristina Simonyan

Affiliations

Soon will be listed here.

Abstract

Introduction: Spasmodic dysphonia (SD) is an isolated focal dystonia characterized by laryngeal spasms during voluntary voice production. Environmental factors have been assumed to play a role in SD pathophysiology; however, the exact extrinsic risk factors and their association with neural alterations remain unknown.

Methods: A total of 186 SD patients and 85 healthy controls completed a structured 177-question survey, consisting of questions on general biographical information, medical history, symptomatology of dystonia. Data were imputed in a stepwise regression model to identify extrinsic risk factors for SD. In addition, functional MRI data from a subset of this cohort were analyzed to determine brain activation abnormalities associated with the SD extrinsic risk.

Results: We found that (1) recurrent upper respiratory infections, gastroesophageal reflux, and neck trauma, all of which influence sensory feedback from the larynx, represent extrinsic risk factors, likely triggering the manifestation of SD symptoms, and (2) neural alterations in the regions necessary for sensorimotor preparation and integration are influenced by an extrinsic risk in susceptible individuals.

Conclusions: These findings provide evidence for the extrinsic risk in SD development and demonstrate the link with alterations in the sensorimotor preparatory network that collectively contribute to the multifactorial pathophysiology of SD.

Citing Articles

Structural and functional brain alterations in laryngeal dystonia: A coordinate-based activation likelihood estimation meta-analysis.

Kshatriya N, Battistella G, Simonyan K Hum Brain Mapp. 2024; 45(14):e70000.

PMID: 39305101 PMC: 11415616. DOI: 10.1002/hbm.70000.

Demographic and clinical characteristics of our patients diagnosed with laryngeal dystonia.

Asya O, Kavak O, Ozden H, Gunal D, Enver N Eur Arch Otorhinolaryngol. 2024; 281(8):4265-4271.

PMID: 38710818 PMC: 11266236. DOI: 10.1007/s00405-024-08688-9.

Exploring Neurophysiological Mechanisms and Treatment Efficacies in Laryngeal Dystonia: A Transcranial Magnetic Stimulation Approach.

Rogic Vidakovic M, Soda J, Kuluva J, Boskovic B, Dolic K, Gunjaca I Brain Sci. 2023; 13(11).

PMID: 38002550 PMC: 10669610. DOI: 10.3390/brainsci13111591.

Temporal Signature of Task-Specificity in Isolated Focal Laryngeal Dystonia.

Ehrlich S, Battistella G, Simonyan K Mov Disord. 2023; 38(10):1925-1935.

PMID: 37489600 PMC: 10615685. DOI: 10.1002/mds.29557.

Clinical Implications of Dystonia as a Neural Network Disorder.

Battistella G, Simonyan K Adv Neurobiol. 2023; 31:223-240.

PMID: 37338705 PMC: 10319344. DOI: 10.1007/978-3-031-26220-3_13.

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