Primary Diffuse Large B Cell Lymphoma of the Common Bile Duct Causing Obstructive Jaundice

Overview

Journal Int Cancer Conf J

Specialty Oncology

Date 2019 Jun 1

PMID 31149436

Citations 3

Authors

Hiroaki Kato

Masanori Tsujie

Tomoko Wakasa

Shuhei Kogata

Hirofumi Kanaizumi

Hiroshi Takeyama

Johji Hara

Kotaro Kitani

Yoshinori Fujiwara

Shigeto Mizuno

Toshihiko Kawasaki

Yoshio Ohta

Masao Yukawa

Masatoshi Inoue

Affiliations

Soon will be listed here.

Abstract

We report a rare case of a diffuse large B-cell lymphoma (DLBCL) arising from the common bile duct (CBD). A 77-year old man presented with general fatigue and obstructive jaundice. Abdominal computed tomography revealed a well-circumscribed enhancing mass in the midportion of the CBD with proximal bile duct dilatation. Endoscopic retrograde cholangiopancreatography (ERCP) also showed a midportion of the CBD stricture. Direct peroral cholangioscopy revealed smooth mass in the midportion of the CBD, and narrow-band imaging (NBI) showed irregular tortuous microvessels. The brushing cytology of the CBD was performed, and it was diagnosed as suspicious for poorly differentiated adenocarcinoma or malignant lymphoma. We performed extrahepatic bile duct resection for accurate diagnosis. Histological and immunohistochemical examination of the resected specimen revealed DLBCL. Although systemic chemotherapy is the mainstay of treatment for DLBCL, he refused scheduled subsequent chemotherapy, and died of multiple liver metastases 6 months after surgery.

Citing Articles

A case of malignant lymphoma of the extrahepatic bile duct diagnosed by detailed imaging examination and endoscopic ultrasound-guided fine needle aspiration.

Iijima N, Nakamura S, Ishii Y, Tatsukawa Y, Ikemoto J, Miyamoto S Clin J Gastroenterol. 2024; 18(1):176-182.

PMID: 39614950 PMC: 11785620. DOI: 10.1007/s12328-024-02075-x.

Unique endoscopic features of primary biliary diffuse large B-cell lymphoma: A case report with literature review (with video).

Nakamura T, Masaki Y, Kameyama N, Kawakami Y, Ishigami K, Takada Y DEN Open. 2024; 5(1):e414.

PMID: 39077549 PMC: 11284119. DOI: 10.1002/deo2.414.

Primary Bile Duct Diffuse Large B-cell Lymphoma Diagnosed by Repeated Endoscopic Ultrasound-guided Fine-needle Aspiration and Endoscopic Retrograde Cholangiopancreatography.

Imai Y, Sekine M, Aoyama K, Kojima S, Sasaki G, Sato A Intern Med. 2023; 63(4):493-501.

PMID: 37344437 PMC: 10937144. DOI: 10.2169/internalmedicine.1776-23.

Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass.

Ohtsubo K, Yamashita K, Yanagimura N, Suzuki C, Tanimoto A, Nishiyama A Intern Med. 2020; 60(3):409-415.

PMID: 32863365 PMC: 7925286. DOI: 10.2169/internalmedicine.5429-20.

References

Oda I, Inui N, Onodera Y, Horimoto M, Watanabe H, Ban N . [An autopsy case of primary non-Hodgkin lymphoma of the extrahepatic bile duct]. Nihon Shokakibyo Gakkai Zasshi. 1999; 96(4):418-22. View

Corbinais S, Caulet-Maugendre S, Pagenault M, Spiliopoulos Y, Dauriac C, Mendler M . [Primary T-cell lymphoma of the common bile duct]. Gastroenterol Clin Biol. 2000; 24(8-9):843-7. View

Eliason S, Grosso L . Primary biliary malignant lymphoma clinically mimicking cholangiocarcinoma: a case report and review of the literature. Ann Diagn Pathol. 2001; 5(1):25-33. DOI: 10.1053/adpa.2001.21483. View

Gravel J, Lallier M, Garel L, Brochu P, Champagne J, Alvarez F . Primary non-Hodgkin lymphoma of the extrahepatic biliary tract and gallbladder in a child. J Pediatr Gastroenterol Nutr. 2001; 32(5):598-601. DOI: 10.1097/00005176-200105000-00021. View

Kang C, Lee Y, Kim S, Kim B . Primary low-grade B cell lymphoma of mucosa-associated lymphoid tissue type of the common bile duct. J Gastroenterol Hepatol. 2001; 16(8):949-51. View

Poggi M, Cong P, Coleman C, Jaffe E . Low-grade follicular lymphoma of the small intestine. J Clin Gastroenterol. 2002; 34(2):155-9. DOI: 10.1097/00004836-200202000-00011. View

Ferluga D, Luzar B, Gadzijev E . Follicular lymphoma of the gallbladder and extrahepatic bile ducts. Virchows Arch. 2003; 442(2):136-40. DOI: 10.1007/s00428-002-0734-6. View

Hans C, Weisenburger D, Greiner T, Gascoyne R, Delabie J, Ott G . Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2003; 103(1):275-82. DOI: 10.1182/blood-2003-05-1545. View

Das K, Fisher A, Wilson D, Dela Torre A, Seguel J, Koneru B . Primary non-Hodgkin's lymphoma of the bile ducts mimicking cholangiocarcinoma. Surgery. 2003; 134(3):496-500. DOI: 10.1067/s0039-6060(03)00149-1. View

10.

Suzuki S, Tanaka S, Suzuki M, Imazato M, Hayashi T, Hanyu F . Mucosa-associated lymphoid tissue-type lymphoproliferative lesion of the common bile duct. Hepatogastroenterology. 2004; 51(55):110-3. View

11.

Joo Y, Park C, Lee W, Kim H, Choi S, Cho C . Primary non-Hodgkin's lymphoma of the common bile duct presenting as obstructive jaundice. J Gastroenterol. 2004; 39(7):692-6. DOI: 10.1007/s00535-004-1367-0. View

12.

Coiffier B . State-of-the-art therapeutics: diffuse large B-cell lymphoma. J Clin Oncol. 2005; 23(26):6387-93. DOI: 10.1200/JCO.2005.05.015. View

13.

Sugawara G, Nagino M, Oda K, Nishio H, Ebata T, Nimura Y . Follicular lymphoma of the extrahepatic bile duct mimicking cholangiocarcinoma. J Hepatobiliary Pancreat Surg. 2008; 15(2):196-9. DOI: 10.1007/s00534-007-1248-z. View

14.

Shito M, Kakefuda T, Omori T, Ishii S, Sugiura H . Primary non-Hodgkin's lymphoma of the main hepatic duct junction. J Hepatobiliary Pancreat Surg. 2008; 15(4):440-3. DOI: 10.1007/s00534-007-1229-2. View

15.

Kosuge T, Makuuchi M, Ozaki H, Kinoshita T, Takenaka T, Mukai K . Primary lymphoma of the common bile duct. Hepatogastroenterology. 1991; 38(3):235-8. View

16.

Dote H, Ohta K, Nishimura R, Teramoto N, Asagi A, Nadano S . Primary extranodal non-Hodgkin's lymphoma of the common bile duct manifesting as obstructive jaundice: report of a case. Surg Today. 2009; 39(5):448-51. DOI: 10.1007/s00595-008-3894-4. View

17.

Christophides T, Samstein B, Emond J, Bhagat G . Primary follicular lymphoma of the extrahepatic bile duct mimicking a hilar cholangiocarcinoma: case report and review of the literature. Hum Pathol. 2009; 40(12):1808-12. DOI: 10.1016/j.humpath.2009.05.012. View

18.

Yoon M, Lee J, Kim S, Lee J, Han J, Choi B . Primary biliary lymphoma mimicking cholangiocarcinoma: a characteristic feature of discrepant CT and direct cholangiography findings. J Korean Med Sci. 2009; 24(5):956-9. PMC: 2752784. DOI: 10.3346/jkms.2009.24.5.956. View

19.

Kang H, Choi J, Seo J, Moon S, Kim J, Jee S . [A case of primary biliary malignant lymphoma mimicking Klatskin tumor]. Korean J Gastroenterol. 2009; 54(3):191-5. DOI: 10.4166/kjg.2009.54.3.191. View

20.

Luigiano C, Ferrara F, Fabbri C, Ghersi S, Bassi M, Polifemo A . Primary lymphoma of the common bile duct presenting with acute pancreatitis and cholangitis. Endoscopy. 2010; 42 Suppl 2:E265-6. DOI: 10.1055/s-0030-1255766. View