CHANGES IN BONE MINERAL PARAMETERS AFTER SLEEVE GASTRECTOMY: RELATIONSHIP WITH GHRELIN AND PLASMA ADIPOKINE LEVELS

Overview

Journal Acta Endocrinol (Buchar)

Specialty Endocrinology

Date 2019 Jun 1

PMID 31149303

Citations 3

Authors

L I Arhire

L Mihalache

S S Padureanu

O Nita

A Gherasim

D Constantinescu

C Preda

Affiliations

Soon will be listed here.

Abstract

Context: Metabolic surgery is currently the most efficient treatment for obesity, but concern is raised about the possible long-term nutritional side effects. Bone metabolism is often adversely affected after surgery, but literature data are contradictory.

Objective: The aim of this study was to evaluate the evolution of bone mass parameters in the first year after laparoscopic sleeve gastrectomy in relation to anthropometric and body composition parameters and specific hormones of obesity.

Design: We conducted a prospective study on 75 patients with obesity that underwent metabolic surgery over a course of 18 months at our center, with a follow-up period of 12 months.

Subjects And Methods: All patients underwent a complex preoperative assessment and were required to return for medical follow-up at 6 and 12 months after surgery. Each visit included anthropometric parameters, DEXA and determination of specific hormonal parameters.

Results: We noticed a significant improvement in anthropometric and body composition parameters after surgery. The value of adiponectin presented a significant increase after surgery and leptin showed a significant decrease at 6 and 12 months postoperative; ghrelin level decreased postoperative compared to preoperative, but without statistical significance. We observed no reduction in BMD after surgery, but a significant improvement in BMC at 12 months after surgery compared to preoperative. Ghrelin negatively correlated to BMD preoperative.

Conclusions: Despite the significant alterations in anthropometric, body composition and hormonal parameters, we found no negative effect on BMD and BMC in our study population.

Citing Articles

Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis.

Huang J, Chen Y, Wang X, Wang C, Yang J, Guan B Obes Surg. 2023; 33(3):789-806.

PMID: 36607567 DOI: 10.1007/s11695-022-06444-8.

The magnitude and progress of lean body mass, fat-free mass, and skeletal muscle mass loss following bariatric surgery: A systematic review and meta-analysis.

Nuijten M, Eijsvogels T, Monpellier V, Janssen I, Hazebroek E, Hopman M Obes Rev. 2021; 23(1):e13370.

PMID: 34664391 PMC: 9285034. DOI: 10.1111/obr.13370.

Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats.

Xue Y, Li R, Zhao Y, Li L, Zhou Y BMC Endocr Disord. 2021; 21(1):173.

PMID: 34445970 PMC: 8394165. DOI: 10.1186/s12902-021-00843-1.

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