ASSOCIATIONS OF THYROID VOLUME AND FUNCTION WITH CHILDHOOD OBESITY

Overview

Journal Acta Endocrinol (Buchar)

Specialty Endocrinology

Date 2019 Jun 1

PMID 31149071

Citations 2

Authors

L Soydan

H Eren Ozturk

Z E Onal

C Nuhoglu

Affiliations

Soon will be listed here.

Abstract

Context: The links between obesity and thyroid function or thyroid volume in children are still controversial with limited available data.

Objective: This study aimed to examine thyroid function and volume in obese Turkish school-age children in comparison to normal-weight children.

Design: Cross-sectional study.

Subjects And Methods: One hundred obese children (47 boys, 53 girls; mean age 10.34±2.79 years) with a body mass index (BMI) above 95th percentile, and 100 normal-weight children (42 boys, 58 girls; 10.34±2.79 years) were included. The study parameters were BMI z score (Z-BMI), body surface area (BSA), thyroid volume, free thyroxine (fT4) and thyroid stimulating hormone (TSH) levels.

Results: The mean TSH and fT4 levels did not show a significant difference between obese and normal-weight children (p>0.05). The mean thyroid volume was higher in obese children (6.46±5.84 and 4.64±1.44, respectively; p=0.043). fT4 correlated negatively with Z-BMI in both normal-weight and obese children (r=-0.285, p=0.004 and r=-0.289, p=0.004, respectively). Thyroid volume, on the other hand, correlated positively with Z-BMI, again in both normal-weight and obese children (r=0.657, p<0.001 and r=0.444, p<0.001, respectively). Similar associations were found for BSA.

Conclusions: Thyroid volume correlated positively and fT4 correlated negatively with Z-BMI and BSA, in both obese and normal-weight school-age children, whereas TSH appears to be independent of these parameters.

Citing Articles

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Wang Y, Dong X, Fu C, Su M, Jiang F, Xu D Front Endocrinol (Lausanne). 2021; 12:662543.

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References

Moncayo R, Ortner K . Multifactorial determinants of cognition - Thyroid function is not the only one. BBA Clin. 2015; 3:289-98. PMC: 4661586. DOI: 10.1016/j.bbacli.2015.04.002. View

Reinehr T, Andler W . Thyroid hormones before and after weight loss in obesity. Arch Dis Child. 2002; 87(4):320-3. PMC: 1763034. DOI: 10.1136/adc.87.4.320. View

Folic N, Folic M, Markovic S, Andjelkovic M, Jankovic S . Risk factors for the development of metabolic syndrome in obese children and adolescents. Srp Arh Celok Lek. 2015; 143(3-4):146-52. DOI: 10.2298/sarh1504146f. View

Gertig A, Niechcial E, Skowronska B . Thyroid axis alterations in childhood obesity. Pediatr Endocrinol Diabetes Metab. 2012; 18(3):116-9. View

Rapa A, Monzani A, Moia S, Vivenza D, Bellone S, Petri A . Subclinical hypothyroidism in children and adolescents: a wide range of clinical, biochemical, and genetic factors involved. J Clin Endocrinol Metab. 2009; 94(7):2414-20. DOI: 10.1210/jc.2009-0375. View

Schumm-Draeger P . Sodium/iodide symporter (NIS) and cytokines. Exp Clin Endocrinol Diabetes. 2001; 109(1):32-4. DOI: 10.1055/s-2001-11018. View

Grandone A, Santoro N, Coppola F, Calabro P, Perrone L, Del Giudice E . Thyroid function derangement and childhood obesity: an Italian experience. BMC Endocr Disord. 2010; 10:8. PMC: 2874556. DOI: 10.1186/1472-6823-10-8. View

Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C . Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9945):766-81. PMC: 4624264. DOI: 10.1016/S0140-6736(14)60460-8. View

Witkowska-Sedek E, Kucharska A, Ruminska M, Pyrzak B . Thyroid dysfunction in obese and overweight children. Endokrynol Pol. 2017; 68(1):54-60. DOI: 10.5603/EP.2017.0007. View

10.

Eliakim A, Barzilai M, Wolach B, Nemet D . Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents?. Int J Pediatr Obes. 2007; 1(4):217-21. DOI: 10.1080/17477160600805006. View

11.

Santos M, Limbert C, Marques F, Rosario F, Lopes L . Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study. J Pediatr Endocrinol Metab. 2015; 28(5-6):557-62. DOI: 10.1515/jpem-2014-0319. View

12.

Biondi B . Thyroid and obesity: an intriguing relationship. J Clin Endocrinol Metab. 2010; 95(8):3614-7. DOI: 10.1210/jc.2010-1245. View

13.

. Recommended normative values for thyroid volume in children aged 6-15 years. World Health Organization & International Council for Control of Iodine Deficiency Disorders. Bull World Health Organ. 1997; 75(2):95-7. PMC: 2486937. View

14.

Marras V, Casini M, Pilia S, Carta D, Civolani P, Porcu M . Thyroid function in obese children and adolescents. Horm Res Paediatr. 2010; 73(3):193-7. DOI: 10.1159/000284361. View

15.

Santini F, Galli G, Maffei M, Fierabracci P, Pelosini C, Marsili A . Acute exogenous TSH administration stimulates leptin secretion in vivo. Eur J Endocrinol. 2010; 163(1):63-7. DOI: 10.1530/EJE-10-0138. View

16.

Fuse Y, Igari T, Yamada C, Sakano S, Ito H, Umenai T . Epidemiological survey of thyroid volume and iodine intake in schoolchildren, postpartum women and neonates living in Ulaan Baatar. Clin Endocrinol (Oxf). 2003; 59(3):298-306. DOI: 10.1046/j.1365-2265.2003.01840.x. View

17.

Ghergherehchi R, Hazhir N . Thyroid hormonal status among children with obesity. Ther Adv Endocrinol Metab. 2015; 6(2):51-5. PMC: 4406880. DOI: 10.1177/2042018815571892. View

18.

Emokpae M, Adeleke S, Uwumarongie H . Subclinical hypothyroidism in childhood obesity and its correlation with lipoproteins. Afr J Med Med Sci. 2012; 40(4):361-5. View

19.

Radetti G, Longhi S, Baiocchi M, Cassar W, Buzi F . Changes in lifestyle improve body composition, thyroid function, and structure in obese children. J Endocrinol Invest. 2011; 35(3):281-5. DOI: 10.3275/7763. View

20.

Radetti G, Kleon W, Buzi F, Crivellaro C, Pappalardo L, Di Iorgi N . Thyroid function and structure are affected in childhood obesity. J Clin Endocrinol Metab. 2008; 93(12):4749-54. DOI: 10.1210/jc.2008-0823. View