Altered Functional Connectivity Associated with Time Discounting in Chronic Pain

Overview

Journal Sci Rep

Specialty Science

Date 2019 Jun 1

PMID 31148557

Citations 9

Authors

Kenta Wakaizumi

Rami Jabakhanji

Naho Ihara

Shizuko Kosugi

Yuri Terasawa

Hiroshi Morisaki

Masao Ogaki

Marwan N Baliki

Affiliations

Soon will be listed here.

Abstract

Chronic pain (CP) is a global problem extensively associated with an unhealthy lifestyle. Time discounting (TD), a tendency to assign less value to future gains than to present gains, is an indicator of the unhealthy behaviors. While, recent neuroimaging studies implied overlapping neuro mechanisms underlying CP and TD, little is known about the specific relationship between CP and TD in behavior or neuroscience. As such, we investigated the association of TD with behavioral measures in CP and resting-state brain functional network in both CP patients and healthy subjects. Behaviorally, TD showed a significant correlation with meaningfulness in healthy subjects, whereas TD in patients only correlated with pain intensity. We identified a specific network including medial and dorsolateral prefrontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed significant indirect mediation effect of meaningfulness on TD. In contrast, TD in patients was correlated with functional connectivity between dorsolateral PFC (DLPFC) and temporal lobe that mediated the effect of pain intensity on TD in patients. These results imply that TD is modulated by pain intensity in CP patients, and the brain function associated to TD is shifted from a medial to lateral representation within the frontal regions.

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References

Cote P, Cassidy D, Carroll L, Kristman V . The annual incidence and course of neck pain in the general population: a population-based cohort study. Pain. 2004; 112(3):267-273. DOI: 10.1016/j.pain.2004.09.004. View

Chen S, Liu M, Cook J, Bass S, Lo S . Sedentary lifestyle as a risk factor for low back pain: a systematic review. Int Arch Occup Environ Health. 2009; 82(7):797-806. DOI: 10.1007/s00420-009-0410-0. View

Apkarian A, Baliki M, Farmer M . Predicting transition to chronic pain. Curr Opin Neurol. 2013; 26(4):360-7. PMC: 4887742. DOI: 10.1097/WCO.0b013e32836336ad. View

Dean E, Soderlund A . What is the role of lifestyle behaviour change associated with non-communicable disease risk in managing musculoskeletal health conditions with special reference to chronic pain?. BMC Musculoskelet Disord. 2015; 16:87. PMC: 4397667. DOI: 10.1186/s12891-015-0545-y. View

Hayden J, Van Tulder M, Tomlinson G . Systematic review: strategies for using exercise therapy to improve outcomes in chronic low back pain. Ann Intern Med. 2005; 142(9):776-85. DOI: 10.7326/0003-4819-142-9-200505030-00014. View

Ariens G, van Mechelen W, Bongers P, Bouter L, van der Wal G . Psychosocial risk factors for neck pain: a systematic review. Am J Ind Med. 2001; 39(2):180-93. DOI: 10.1002/1097-0274(200102)39:2<180::aid-ajim1005>3.0.co;2-#. View

de Heer E, Gerrits M, Beekman A, Dekker J, van Marwijk H, de Waal M . The association of depression and anxiety with pain: a study from NESDA. PLoS One. 2014; 9(10):e106907. PMC: 4198088. DOI: 10.1371/journal.pone.0106907. View

Mansour A, Baria A, Tetreault P, Vachon-Presseau E, Chang P, Huang L . Global disruption of degree rank order: a hallmark of chronic pain. Sci Rep. 2016; 6:34853. PMC: 5057075. DOI: 10.1038/srep34853. View

Pisinger C, Aadahl M, Toft U, Birke H, Zytphen-Adeler J, Jorgensen T . The association between active and passive smoking and frequent pain in a general population. Eur J Pain. 2010; 15(1):77-83. DOI: 10.1016/j.ejpain.2010.05.004. View

10.

Neubert F, Mars R, Sallet J, Rushworth M . Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex. Proc Natl Acad Sci U S A. 2015; 112(20):E2695-704. PMC: 4443352. DOI: 10.1073/pnas.1410767112. View

11.

Fayaz A, Croft P, Langford R, Donaldson L, Jones G . Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies. BMJ Open. 2016; 6(6):e010364. PMC: 4932255. DOI: 10.1136/bmjopen-2015-010364. View

12.

Boakye P, Olechowski C, Rashiq S, Verrier M, Kerr B, Witmans M . A Critical Review of Neurobiological Factors Involved in the Interactions Between Chronic Pain, Depression, and Sleep Disruption. Clin J Pain. 2015; 32(4):327-36. DOI: 10.1097/AJP.0000000000000260. View

13.

Seminowicz D, Wideman T, Naso L, Hatami-Khoroushahi Z, Fallatah S, Ware M . Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function. J Neurosci. 2011; 31(20):7540-50. PMC: 6622603. DOI: 10.1523/JNEUROSCI.5280-10.2011. View

14.

Tetreault P, Mansour A, Vachon-Presseau E, Schnitzer T, Apkarian A, Baliki M . Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials. PLoS Biol. 2016; 14(10):e1002570. PMC: 5082893. DOI: 10.1371/journal.pbio.1002570. View

15.

Baliki M, Petre B, Torbey S, Herrmann K, Huang L, Schnitzer T . Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci. 2012; 15(8):1117-9. PMC: 3411898. DOI: 10.1038/nn.3153. View

16.

Wakaizumi K, Yamada K, Oka H, Kosugi S, Morisaki H, Shibata M . Fear-avoidance beliefs are independently associated with the prevalence of chronic pain in Japanese workers. J Anesth. 2017; 31(2):255-262. DOI: 10.1007/s00540-016-2303-1. View

17.

Pulcu E, Trotter P, Thomas E, McFarquhar M, Juhasz G, Sahakian B . Temporal discounting in major depressive disorder. Psychol Med. 2013; 44(9):1825-34. PMC: 4035754. DOI: 10.1017/S0033291713002584. View

18.

Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D . Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2005; 10(4):287-333. DOI: 10.1016/j.ejpain.2005.06.009. View

19.

Penninx B, Beekman A, Smit J, Zitman F, Nolen W, Spinhoven P . The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods. Int J Methods Psychiatr Res. 2008; 17(3):121-40. PMC: 6878352. DOI: 10.1002/mpr.256. View

20.

Mutso A, Petre B, Huang L, Baliki M, Torbey S, Herrmann K . Reorganization of hippocampal functional connectivity with transition to chronic back pain. J Neurophysiol. 2013; 111(5):1065-76. PMC: 3949236. DOI: 10.1152/jn.00611.2013. View