GABAergic-astrocyte Signaling: A Refinement of Inhibitory Brain Networks

Overview

Journal Glia

Specialty Neurology

Date 2019 May 31

PMID 31145508

Citations 59

Authors

Sara Mederos

Gertrudis Perea

Affiliations

Soon will be listed here.

Abstract

Interneurons play a critical role in precise control of network operation. Indeed, higher brain capabilities such as working memory, cognitive flexibility, attention, or social interaction rely on the action of GABAergic interneurons. Evidence from excitatory neurons and synapses has revealed astrocytes as integral elements of synaptic transmission. However, GABAergic interneurons can also engage astrocyte signaling; therefore, it is tempting to speculate about different scenarios where, based on particular interneuron cell type, GABAergic-astrocyte interplay would be involved in diverse outcomes of brain function. In this review, we will highlight current data supporting the existence of dynamic GABAergic-astrocyte communication and its impact on the inhibitory-regulated brain responses, bringing new perspectives on the ways astrocytes might contribute to efficient neuronal coding.

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