A Meta-analysis of the Association Between the Presence of Helicobacter Pylori and Periodontal Diseases

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2019 May 31

PMID 31145357

Citations 2

Authors

Zheng Chen

Jiarong Cai

Yi-Ming Chen

Jiaming Wei

Hui-Biao Li

Yeming Lu

Zhengyang Zhou

Xin-Lin Chen

Affiliations

Soon will be listed here.

Abstract

Background: The objective of this meta-analysis is to evaluate the association between the presence of Helicobacter pylori (H pylori) and periodontal disease (PD).

Methods: PubMed and EMBASE databases were searched to identify eligible articles published from inception up to April 2018. Further articles were retrieved through a manual search of recent reviews. Cross-sectional studies, case-control studies and cohort studies reporting the association between H pylori and PD were included. The pooled odds ratio (OR) and their 95% confidence interval (CI) were calculated.

Results: Four case-control studies and nine cross-sectional studies were included. A total of 6800 patients were included in this review. The odds for oral H pylori positivity was 2.31 times (95% CI: 1.99-2.68) greater than those without H pylori. Subgroup analyses involving different study locations, designs, and types of study population showed the similar results. The pooled OR for the gastric disease patients was the largest (3.50, 95% CI: 2.22-5.53, five articles). Stomach H pylori was also significantly associated with PD, with OR 2.90 (95% CI: 1.37-6.14, two articles).

Conclusions: This meta-analysis supports an association between H pylori and PD. More well-designed studies, especially prospective cohort studies are necessary to confirm these results.

Citing Articles

Helicobacter pylori, periodontal pathogens, and their interactive association with incident all-cause and Alzheimer's disease dementia in a large national survey.

Beydoun M, Beydoun H, Weiss J, Hossain S, El-Hajj Z, Zonderman A Mol Psychiatry. 2020; 26(10):6038-6053.

PMID: 32366948 DOI: 10.1038/s41380-020-0736-2.

Periodontitis and oral cancer - current concepts of the etiopathogenesis.

Irani S, Barati I, Badiei M Oncol Rev. 2020; 14(1):465.

PMID: 32231765 PMC: 7097927. DOI: 10.4081/oncol.2020.465.

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