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Genotypes of Clinical Varicella-zoster Virus Isolates from Manaus, Brazil

Overview
Journal Rev Soc Bras Med Trop
Specialty Tropical Medicine
Date 2019 May 30
PMID 31141042
Citations 1
Authors
Michele de Souza Bastos
Jennifer Folster
Otavio Primo de Alvarenga
Daniele de Araujo Sampaio
Ronaldo Marques Pontes Rabelo
Guilherme Augusto Pivoto Joao
Marcus Vinicius Guimaraes de Lacerda
D Scott Schmid
Affiliations
Soon will be listed here.
Abstract

Introduction: Vaccination against varicella-zoster virus (VZV) has been effective and safe in countries that routinely administer the vaccine. Brazil began universal VZV vaccination in 2013. This study aimed to identify VZV genotypes present in Manaus, Brazil prior to widespread immunization.

Methods: Vesicular lesions or cerebral-spinal-fluid samples were collected from patients diagnosed with VZV, herpes zoster, or meningitis/encephalitis. DNA was extracted, amplified, and sequenced.

Results: Half the isolates were clade-5 viruses and the remaining were divided between the European clades 1 and 3.

Conclusions: This study provides insights into the circulating VZV genotypes in Manaus prior to widespread vaccination.

Citing Articles

Phylogenetic Analysis of Varicella-Zoster Virus in Cerebrospinal Fluid from Individuals with Acute Central Nervous System Infection: An Exploratory Study.

Paiao H, da Costa A, Ferreira N, Honorato L, Santos B, de Matos M Viruses. 2025; 17(2).

PMID: 40007041 PMC: 11860453. DOI: 10.3390/v17020286.

Vaccine Strain and Wild-Type Clades of Varicella-Zoster Virus in Central Nervous System and Non-CNS Disease, New York State, 2004-2019.

Bryant P, Yildirim T, Griesemer S, Shaw K, Ehrbar D, St George K J Clin Microbiol. 2022; 60(4):e0238121.

PMID: 35321554 PMC: 9020340. DOI: 10.1128/jcm.02381-21.

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