Diffuse Large B Cell Lymphoma Secondary to JC Virus in Progressive Multifocal Leukoencephalopathy

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2019 May 30

PMID 31140130

Citations 3

Authors

Ashwin Reddi

Nikhil Patel

Nicholas A Morris

Affiliations

Soon will be listed here.

Abstract

We present the case of a 43-year-old-man with a past medical history of HIV with recently initiated HAART and existing PML that presented with altered mental status. The initial diagnosis was deemed to be PML-IRIS; however, neuroimaging brought into question this diagnosis. Flow cytometry performed from the cerebrospinal fluid revealed diffuse large B cell lymphoma. JC virus may act in an oncogenic role similarly to EBV and predispose to CNS lymphomas. Patients with PML caused by JC virus may develop secondary malignancies.

Citing Articles

The Possible Role of Pathogens and Chronic Immune Stimulation in the Development of Diffuse Large B-Cell Lymphoma.

Gergely L, Udvardy M, Illes A Biomedicines. 2024; 12(3).

PMID: 38540261 PMC: 10967989. DOI: 10.3390/biomedicines12030648.

Co-Detection of EBV and Human Polyomavirus JCPyV in a Case of AIDS-Related Multifocal Primary Central Nervous System Diffuse Large B-Cell Lymphoma.

Barbier M, Del Valle L Viruses. 2023; 15(3).

PMID: 36992464 PMC: 10059075. DOI: 10.3390/v15030755.

The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis.

Zheng H, E Y, Cui Z, Zhao S, Zhang Y Front Mol Biosci. 2021; 8:687444.

PMID: 34476239 PMC: 8406522. DOI: 10.3389/fmolb.2021.687444.

References

Antinori A, Cingolani A, Lorenzini P, Giancola M, Uccella I, Bossolasco S . Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA). J Neurovirol. 2003; 9 Suppl 1:47-53. DOI: 10.1080/13550280390195388. View

Chapagain M, Nerurkar V . Human polyomavirus JC (JCV) infection of human B lymphocytes: a possible mechanism for JCV transmigration across the blood-brain barrier. J Infect Dis. 2010; 202(2):184-91. PMC: 2928669. DOI: 10.1086/653823. View

Barzon L, Trevisan M, Marino F, Guzzardo V, Palu G . Primary bilateral adrenal B-cell lymphoma associated with EBV and JCV infection. Infect Agent Cancer. 2009; 4:1. PMC: 2630304. DOI: 10.1186/1750-9378-4-1. View

Dojcinov S, Fend F, Quintanilla-Martinez L . EBV-Positive Lymphoproliferations of B- T- and NK-Cell Derivation in Non-Immunocompromised Hosts. Pathogens. 2018; 7(1). PMC: 5874754. DOI: 10.3390/pathogens7010028. View

Wei G, Liu C, Atwood W . JC virus binds to primary human glial cells, tonsillar stromal cells, and B-lymphocytes, but not to T lymphocytes. J Neurovirol. 2000; 6(2):127-36. DOI: 10.3109/13550280009013156. View

Krynska B, Del Valle L, Croul S, Gordon J, Katsetos C, Carbone M . Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. Proc Natl Acad Sci U S A. 1999; 96(20):11519-24. PMC: 18066. DOI: 10.1073/pnas.96.20.11519. View

Shah R, Bag A, Chapman P, Cure J . Imaging manifestations of progressive multifocal leukoencephalopathy. Clin Radiol. 2010; 65(6):431-9. DOI: 10.1016/j.crad.2010.03.001. View

Ratnam I, Chiu C, Kandala N, Easterbrook P . Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort. Clin Infect Dis. 2006; 42(3):418-27. DOI: 10.1086/499356. View

Tan C, Koralnik I . Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010; 9(4):425-37. PMC: 2880524. DOI: 10.1016/S1474-4422(10)70040-5. View

10.

Metz I, Radue E, Oterino A, Kumpfel T, Wiendl H, Schippling S . Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol. 2011; 123(2):235-45. PMC: 3259335. DOI: 10.1007/s00401-011-0900-5. View

11.

Hernandez-Losa J, Fedele C, Pozo F, Tenorio A, Fernandez V, Castellvi J . Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas. Cancer. 2004; 103(2):293-8. DOI: 10.1002/cncr.20801. View

12.

Guiguet M, Boue F, Cadranel J, Lang J, Rosenthal E, Costagliola D . Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol. 2009; 10(12):1152-9. DOI: 10.1016/S1470-2045(09)70282-7. View

13.

Gallia G, DelValle L, Laine C, Curtis M, Khalili K . Concomitant progressive multifocal leucoencephalopathy and primary central nervous system lymphoma expressing JC virus oncogenic protein, large T antigen. Mol Pathol. 2001; 54(5):354-9. PMC: 1187095. DOI: 10.1136/mp.54.5.354. View

14.

Del Valle L, Enam S, Lara C, Miklossy J, Khalili K, Gordon J . Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus, genome. J Virol. 2004; 78(7):3462-9. PMC: 371040. DOI: 10.1128/jvi.78.7.3462-3469.2004. View

15.

Mantina H, Wiggill T, Carmona S, Perner Y, Stevens W . Characterization of Lymphomas in a high prevalence HIV setting. J Acquir Immune Defic Syndr. 2010; 53(5):656-60. DOI: 10.1097/QAI.0b013e3181bf5544. View

16.

Cesarman E . Epstein-Barr virus (EBV) and lymphomagenesis. Front Biosci. 2002; 7:e58-65. DOI: 10.2741/A907. View

17.

Major E, Amemiya K, Tornatore C, Houff S, Berger J . Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev. 1992; 5(1):49-73. PMC: 358223. DOI: 10.1128/CMR.5.1.49. View

18.

Sainz-de-la-Maza S, Casado J, Perez-Elias M, Moreno A, Quereda C, Moreno S . Incidence and prognosis of immune reconstitution inflammatory syndrome in HIV-associated progressive multifocal leucoencephalopathy. Eur J Neurol. 2016; 23(5):919-25. DOI: 10.1111/ene.12963. View

19.

Manabe Y, Campbell J, Sydnor E, Moore R . Immune reconstitution inflammatory syndrome: risk factors and treatment implications. J Acquir Immune Defic Syndr. 2007; 46(4):456-62. DOI: 10.1097/qai.0b013e3181594c8c. View

20.

Tan K, Roda R, Ostrow L, McArthur J, Nath A . PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology. 2009; 72(17):1458-64. PMC: 2677476. DOI: 10.1212/01.wnl.0000343510.08643.74. View