Pharmacokinetics of Various Preparations of Organic Nitrates

Overview

Journal Drugs

Specialty Pharmacology

Date 1987 Jan 1

PMID 3113910

Citations 4

Authors

J P Kampmann

Affiliations

Soon will be listed here.

Abstract

The pharmacokinetics of different formulations of glyceryl trinitrate, isosorbide dinitrate, isosorbide 5-mononitrate and isosorbide 2-mononitrate are reviewed.

Citing Articles

Isosorbide 5-mononitrate: a review of a sustained-release formulation (Imdur) in stable angina pectoris.

Gunasekara N, Noble S Drugs. 1999; 57(2):261-77.

PMID: 10188765 DOI: 10.2165/00003495-199957020-00016.

Clinical pharmacokinetics in heart failure. An updated review.

Shammas F, Dickstein K Clin Pharmacokinet. 1988; 15(2):94-113.

PMID: 3064953 DOI: 10.2165/00003088-198815020-00002.

Transdermal nitroglycerin (glyceryl trinitrate). A review of its pharmacology and therapeutic use.

Todd P, Goa K, Langtry H Drugs. 1990; 40(6):880-902.

PMID: 2127741 DOI: 10.2165/00003495-199040060-00009.

Prophylactic nitrate therapy in angina pectoris--is there an optimal treatment regimen?.

Olsson G, Allgen J Br J Clin Pharmacol. 1992; 34 Suppl 1:19S-23S.

PMID: 1633074 PMC: 1381218. DOI: 10.1111/j.1365-2125.1992.tb04144.x.

References

Straehl P, Galeazzi R . Isosorbide dinitrate bioavailability, kinetics, and metabolism. Clin Pharmacol Ther. 1985; 38(2):140-9. DOI: 10.1038/clpt.1985.150. View

Sorkin E, Brogden R, Romankiewicz J . Intravenous glyceryl trinitrate (nitroglycerin). A review of its pharmacological properties and therapeutic efficacy. Drugs. 1984; 27(1):45-80. DOI: 10.2165/00003495-198427010-00003. View

Straehl P, Galeazzi R, Soliva M . Isosorbide 5-mononitrate and isosorbide 2-mononitrate kinetics after intravenous and oral dosing. Clin Pharmacol Ther. 1984; 36(4):485-92. DOI: 10.1038/clpt.1984.208. View

Major R, Taylor T, Chasseaud L, Darragh A, Lambe R . Isosorbide 5-mononitrate kinetics. Clin Pharmacol Ther. 1984; 35(5):653-9. DOI: 10.1038/clpt.1984.90. View

BETZIEN G, Kaufmann B, Liede V, Abshagen U . Effects and pharmacokinetics of isosorbide dinitrate in normal man. Eur J Clin Pharmacol. 1980; 18(3):237-44. DOI: 10.1007/BF00563005. View

McNiff E, Yacobi A, GOLDEN L, Goldfarb A, Fung H . Nitroglycerin pharmacokinetics after intravenous infusion in normal subjects. J Pharm Sci. 1981; 70(9):1054-8. DOI: 10.1002/jps.2600700923. View

Wei J, Reid P . Quantitative determination of trinitroglycerin in human plasma. Circulation. 1979; 59(3):588-92. DOI: 10.1161/01.cir.59.3.588. View

Abshagen U . First data on effects and pharmacokinetics of isosorbide-5-mononitrate in normal man. Eur J Clin Pharmacol. 1981; 19(6):423-9. DOI: 10.1007/BF00548586. View

Steudel H, Volkenandt M, Steudel A . Pharmacokinetics of isosorbide-5-mononitrate after oral and intravenous administration in patients with liver cirrhosis: first results. Z Kardiol. 1983; 72 Suppl 3:24-8. View

10.

Platzer R, Reutemann G, Galeazzi R . Pharmacokinetics of intravenous isosorbide-dinitrate. J Pharmacokinet Biopharm. 1982; 10(6):575-86. DOI: 10.1007/BF01062541. View

11.

Armstrong P, Armstrong J, Marks G . Pharmacokinetic-hemodynamic studies of intravenous nitroglycerin in congestive cardiac failure. Circulation. 1980; 62(1):160-6. DOI: 10.1161/01.cir.62.1.160. View

12.

Kosters W, Klotschkoff P, Abshagen U . [Pharmacokinetics of isosorbide-5-mononitrate in patients with advanced renal failure]. Med Welt. 1981; 32(14A):521-3. View

13.

Morrison R, Wiegand U, Jahnchen E, Hohmann D, Bechtold H, Meinertz T . Isosorbide dinitrate kinetics and dynamics after intravenous, sublingual, and percutaneous dosing in angina. Clin Pharmacol Ther. 1983; 33(6):747-56. DOI: 10.1038/clpt.1983.102. View

14.

Olivari M, Cohn J . Cutaneous administration of nitroglycerin: a review. Pharmacotherapy. 1983; 3(3):149-57. DOI: 10.1002/j.1875-9114.1983.tb03242.x. View

15.

Wood S, John B, Chasseaud L, Major R, Forrest M, Bonn R . Metabolic fact of 14C-isosorbide 5-mononitrate in humans. Arzneimittelforschung. 1984; 34(9):1031-5. View

16.

Fung H . Nitrate formulations and drug delivery systems--an overview. Z Kardiol. 1985; 74 Suppl 4:4-9. View

17.

Bashir A, Lewis M, Henderson A . Pharmacokinetic studies of various preparations of glyceryl trinitrate. Br J Clin Pharmacol. 1982; 14(6):779-84. PMC: 1427551. DOI: 10.1111/j.1365-2125.1982.tb02036.x. View

18.

Taylor T, Chasseaud L, Major R, Doyle E, Darragh A . Isosorbide 5-mononitrate pharmacokinetics in humans. Biopharm Drug Dispos. 1981; 2(3):255-63. DOI: 10.1002/bdd.2510020306. View

19.

Givant Y, SULMAN F . Quantitation of nitroglycerin in human blood after administration by sustained release. Experientia. 1978; 34(5):643-4. DOI: 10.1007/BF01937010. View

20.

Bogaert M, Rosseel M, Boelaert J, DANEELS R . Fate of isosorbide dinitrate and mononitrates in patients with renal failure. Eur J Clin Pharmacol. 1981; 21(1):73-6. DOI: 10.1007/BF00609591. View