Fengycin Produced by FZB42 Inhibits Growth and Mycotoxins Biosynthesis

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2019 May 30

PMID 31137632

Citations 50

Authors

Alvina Hanif

Feng Zhang

Pingping Li

Chuchu Li

Yujiao Xu

Muhammad Zubair

Mengxuan Zhang

Dandan Jia

Xiaozhen Zhao

Jingang Liang

Taha Majid

Jingyuau Yan

Ayaz Farzand

Huijun Wu

Qin Gu

Xuewen Gao

Affiliations

Soon will be listed here.

Abstract

is a notorious pathogen that causes Fusarium head blight (FHB) in cereal crops. It produces secondary metabolites, such as deoxynivalenol, diminishing grain quality and leading to lesser crop yield. Many strategies have been developed to combat this pathogenic fungus; however, considering the lack of resistant cultivars and likelihood of environmental hazards upon using chemical pesticides, efforts have shifted toward the biocontrol of plant diseases, which is a sustainable and eco-friendly approach. Fengycin, derived from FZB42, was purified from the crude extract by HPLC and further analyzed by MALDI-TOF-MS. Its application resulted in structural deformations in fungal hyphae, as observed via scanning electron microscopy. In planta experiment revealed the ability of fengycin to suppress growth and highlighted its capacity to combat disease incidence. Fengycin significantly suppressed , and also reduced the deoxynivalenol (DON), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), and zearalenone (ZEN) production in infected grains. To conclude, we report that fengycin produced by FZB42 has potential as a biocontrol agent against and can also inhibit the mycotoxins produced by this fungus.

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