The LiaFSR and BsrXRS Systems Contribute to Bile Salt Resistance in Isolates

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2019 May 29

PMID 31134041

Citations 5

Authors

Luoxiong Zhou

Lihong Wang

Ping Tian

Tingting Bao

Lianbin Li

Xin Zhao

Affiliations

Soon will be listed here.

Abstract

Two-component systems (TCSs) are dominant regulating components in bacteria for responding to environmental stimuli. However, little information is available on how TCSs in respond to bile salts - an important environmental stimulus for intestinal bacteria. In this study, the gene expression of 2 TCSs, BsrXRS and LiaFSR, was positively correlated with survival rates of different isolates during exposure to ox gall. Moreover, gene disruptions of , , , and significantly reduced the survival rates of in the presence of ox gall. Finally, EMSA results indicated that BsrR functioned as a transcription regulator for expression of its own gene as well as lipoate-protein ligase A (). Additional 27 potential target genes by BsrR were revealed through analyses. These findings suggest that BsrXRS and LiaFSR systems play important roles in bile salt resistance in .

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