Rheumatoid Nodules in Thyroid Gland Parenchyma As an Expression of Rheumatoid Arthritis: a Case Report

Overview

Journal J Med Case Rep

Publisher Biomed Central

Specialty General Medicine

Date 2019 May 29

PMID 31133043

Citations 1

Authors

Efthimios Sivridis

Maria Kouroupi

Michael Ioannis Koukourakis

Stella Arelaki

Nikolaos Lyratzopoulos

Alexandra Giatromanolaki

Affiliations

Soon will be listed here.

Abstract

Background: The rheumatoid nodule is the most common extra-articular manifestation of rheumatoid arthritis. When present, it is readily identified in conventional hematoxylin and eosin sections.

Case Presentation: We report a case with several rheumatoid nodules in a thyroid gland of a 33-year-old Greek woman with a 3-year history of rheumatoid arthritis treated with methotrexate, after having total thyroidectomy for hypothyroidism.

Conclusion: To the best of our knowledge, this is the first time that rheumatoid nodules have been encountered in the thyroid gland.

Citing Articles

Rheumatoid Nodule Simulating a Parotid Tumor.

Martins S, Fernandes B, Bernardes M, Melo D, Neto T Head Neck Pathol. 2020; 15(1):334-340.

PMID: 32436170 PMC: 8010028. DOI: 10.1007/s12105-020-01175-7.

References

Nadkar M, Agarwal R, Samant R, Chhugani S, Idgunji S, Iyer S . Neuropathy in rheumatoid arthritis. J Assoc Physicians India. 2001; 49:217-20. View

Solomon D, Karlson E, Rimm E, Cannuscio C, Mandl L, Manson J . Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation. 2003; 107(9):1303-7. DOI: 10.1161/01.cir.0000054612.26458.b2. View

Carmona L, Gonzalez-Alvaro I, Balsa A, Angel Belmonte M, Tena X, Sanmarti R . Rheumatoid arthritis in Spain: occurrence of extra-articular manifestations and estimates of disease severity. Ann Rheum Dis. 2003; 62(9):897-900. PMC: 1754657. DOI: 10.1136/ard.62.9.897. View

Charles C, Bialy T, Falabella A, Eaglstein W, Kerdel F, Kirsner R . Poor prognosis of arthritis-associated pyoderma gangrenosum. Arch Dermatol. 2004; 140(7):861-4. DOI: 10.1001/archderm.140.7.861. View

Agrawal S, Misra R, Aggarwal A . Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients. Rheumatol Int. 2006; 26(12):1091-5. DOI: 10.1007/s00296-006-0133-4. View

Cronstein B . Interleukin-6--a key mediator of systemic and local symptoms in rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007; 65 Suppl 1:S11-5. View

Hochberg M, Johnston S, John A . The incidence and prevalence of extra-articular and systemic manifestations in a cohort of newly-diagnosed patients with rheumatoid arthritis between 1999 and 2006. Curr Med Res Opin. 2008; 24(2):469-80. DOI: 10.1185/030079908x261177. View

Al-Ghamdi A, Attar S . Extra-articular manifestations of rheumatoid arthritis: a hospital-based study. Ann Saudi Med. 2009; 29(3):189-93. PMC: 2813651. DOI: 10.4103/0256-4947.51774. View

Scott D, Wolfe F, Huizinga T . Rheumatoid arthritis. Lancet. 2010; 376(9746):1094-108. DOI: 10.1016/S0140-6736(10)60826-4. View

10.

Cojocaru M, Cojocaru I, Silosi I, Vrabie C, Tanasescu R . Extra-articular Manifestations in Rheumatoid Arthritis. Maedica (Bucur). 2011; 5(4):286-91. PMC: 3152850. View

11.

Yachoui R, Ward C, Kreidy M . A rheumatoid nodule in an unusual location: mediastinal lymph node. BMJ Case Rep. 2013; 2013. PMC: 3669837. DOI: 10.1136/bcr-2013-009516. View

12.

Cutolo M, Kitas G, van Riel P . Burden of disease in treated rheumatoid arthritis patients: going beyond the joint. Semin Arthritis Rheum. 2013; 43(4):479-88. DOI: 10.1016/j.semarthrit.2013.08.004. View

13.

Bhargava A, Hegde P, Tallapureddy S, Varghese S, Forouhar F, Tendler B . Rheumatoid nodules in the thyroid bed following total thyroidectomy: a case report. J Med Case Rep. 2013; 7:247. PMC: 3843512. DOI: 10.1186/1752-1947-7-247. View

14.

Nagnur-Mehta P, Chitnis N, Joshi V . Subcutaneous nodules in rheumatoid arthritis. J Assoc Physicians India. 2014; 61(2):136. View

15.

Chakraborty P . Methotrexate-induced accelerated nodulosis in seropositive rheumatoid arthritis. J Assoc Physicians India. 2014; 61(4):274. View

16.

Kato K, Segami N, Fukuda H, Minato H . Rheumatoid nodule in the lower lip of a patient with rheumatoid arthritis: a novel case report and review of literature. J Oral Maxillofac Surg. 2014; 72(8):1532.e1-5. DOI: 10.1016/j.joms.2014.03.034. View

17.

Nakamura T, Inaba M, Yoshinaga T, Takaoka H, Iyama K . Nodules in patients with rheumatoid arthritis and methotrexate treatment. Mod Rheumatol. 2015; 25(5):812-3. DOI: 10.3109/14397595.2014.928424. View

18.

Takashima S, Ota M . Methotrexate-induced nodulosis. CMAJ. 2015; 187(10):E327. PMC: 4500730. DOI: 10.1503/cmaj.140852. View

19.

Tilstra J, Lienesch D . Rheumatoid Nodules. Dermatol Clin. 2015; 33(3):361-71. DOI: 10.1016/j.det.2015.03.004. View

20.

Sagdeo P, Gattimallanahali Y, Kakade G, Canchi B . Rheumatoid lung nodule. BMJ Case Rep. 2015; 2015. PMC: 4636694. DOI: 10.1136/bcr-2015-213083. View