Metadherin: A Therapeutic Target in Multiple Cancers

Overview

Journal Front Oncol

Specialty Oncology

Date 2019 May 28

PMID 31131259

Citations 40

Authors

Gourav Dhiman

Neha Srivastava

Mehendi Goyal

Emad Rakha

Jennifer Lothion-Roy

Nigel P Mongan

Regina R Miftakhova

Svetlana F Khaiboullina

Albert A Rizvanov

Manoj Baranwal

Affiliations

Soon will be listed here.

Abstract

Altered expression of many genes and proteins is essential for cancer development and progression. Recently, the affected expression of metadherin (MTDH), also known as AEG-1 (Astrocyte Elevated Gene 1) and Lyric, has been implicated in various aspects of cancer progression and metastasis. Elevated expression of MTDH/AEG-1 has been reported in many cancers including breast, prostate, liver, and esophageal cancers, whereas its expression is low or absent in non-malignant tissues. These expression studies suggest that MTDH may represent a potential tumor associated antigen. MTDH also regulates multiple signaling pathways including PI3K/Akt, NF-κB, Wnt/β-catenin, and MAPK which cooperate to promote the tumorigenic and metastatic potential of transformed cells. Several microRNA have also been found to be associated with the increased MTDH expression in different cancers. Increased MTDH levels were linked to the tumor chemoresistance making it an attractive novel therapeutic target. In this review, we summarize data on MTDH function in various cancers.

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