Lipoxidation Targets: From Basic Mechanisms to Pathophysiology

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2019 May 27

PMID 31129033

Citations 1

Authors

Dolores Perez-Sala

Rosario Domingues

Affiliations

Soon will be listed here.

Citing Articles

Protein Lipoxidation: Basic Concepts and Emerging Roles.

Viedma-Poyatos A, Gonzalez-Jimenez P, Langlois O, Company-Marin I, Spickett C, Perez-Sala D Antioxidants (Basel). 2021; 10(2).

PMID: 33669164 PMC: 7919664. DOI: 10.3390/antiox10020295.

References

Schopfer F, Cipollina C, Freeman B . Formation and signaling actions of electrophilic lipids. Chem Rev. 2011; 111(10):5997-6021. PMC: 3294277. DOI: 10.1021/cr200131e. View

Monico A, Duarte S, Pajares M, Perez-Sala D . Vimentin disruption by lipoxidation and electrophiles: Role of the cysteine residue and filament dynamics. Redox Biol. 2019; 23:101098. PMC: 6859561. DOI: 10.1016/j.redox.2019.101098. View

Rojo de la Vega M, Chapman E, Zhang D . NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018; 34(1):21-43. PMC: 6039250. DOI: 10.1016/j.ccell.2018.03.022. View

Domingues R, Domingues P, Melo T, Perez-Sala D, Reis A, Spickett C . Lipoxidation adducts with peptides and proteins: deleterious modifications or signaling mechanisms?. J Proteomics. 2013; 92:110-31. DOI: 10.1016/j.jprot.2013.06.004. View

Zarkovic K, Jakovcevic A, Zarkovic N . Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases. Free Radic Biol Med. 2016; 111:110-126. DOI: 10.1016/j.freeradbiomed.2016.12.009. View

Di Domenico F, Tramutola A, Barone E, Lanzillotta C, Defever O, Arena A . Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome. Redox Biol. 2019; 23:101162. PMC: 6859577. DOI: 10.1016/j.redox.2019.101162. View

Zarkovic K . 4-hydroxynonenal and neurodegenerative diseases. Mol Aspects Med. 2003; 24(4-5):293-303. DOI: 10.1016/s0098-2997(03)00024-4. View

Gianazza E, Brioschi M, Martinez Fernandez A, Banfi C . Lipoxidation in cardiovascular diseases. Redox Biol. 2019; 23:101119. PMC: 6859589. DOI: 10.1016/j.redox.2019.101119. View

Jacobs A, Marnett L . Systems analysis of protein modification and cellular responses induced by electrophile stress. Acc Chem Res. 2010; 43(5):673-83. PMC: 2873822. DOI: 10.1021/ar900286y. View

10.

Melo T, Montero-Bullon J, Domingues P, Domingues M . Discovery of bioactive nitrated lipids and nitro-lipid-protein adducts using mass spectrometry-based approaches. Redox Biol. 2019; 23:101106. PMC: 6859590. DOI: 10.1016/j.redox.2019.101106. View

11.

Mol M, Degani G, Coppa C, Baron G, Popolo L, Carini M . Advanced lipoxidation end products (ALEs) as RAGE binders: Mass spectrometric and computational studies to explain the reasons why. Redox Biol. 2019; 23:101083. PMC: 6859533. DOI: 10.1016/j.redox.2018.101083. View

12.

de Dios Alche J . A concise appraisal of lipid oxidation and lipoxidation in higher plants. Redox Biol. 2019; 23:101136. PMC: 6859586. DOI: 10.1016/j.redox.2019.101136. View

13.

Lee E, Kim S, Hahn Y, Yoon H, Han B, Kim K . 15-Keto prostaglandin E suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019; 23:101175. PMC: 6859578. DOI: 10.1016/j.redox.2019.101175. View

14.

Coliva G, Duarte S, Perez-Sala D, Fedorova M . Impact of inhibition of the autophagy-lysosomal pathway on biomolecules carbonylation and proteome regulation in rat cardiac cells. Redox Biol. 2019; 23:101123. PMC: 6859560. DOI: 10.1016/j.redox.2019.101123. View

15.

Diez-Dacal B, Gayarre J, Gharbi S, Timms J, Coderch C, Gago F . Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity. Cancer Res. 2011; 71(12):4161-71. DOI: 10.1158/0008-5472.CAN-10-3816. View

16.

Schopfer F, Vitturi D, Jorkasky D, Freeman B . Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases. Nitric Oxide. 2018; 79:31-37. PMC: 6280193. DOI: 10.1016/j.niox.2018.06.006. View

17.

Aldini G, Domingues M, Spickett C, Domingues P, Altomare A, Sanchez-Gomez F . Protein lipoxidation: Detection strategies and challenges. Redox Biol. 2015; 5:253-266. PMC: 4477048. DOI: 10.1016/j.redox.2015.05.003. View

18.

Jove M, Pradas I, Dominguez-Gonzalez M, Ferrer I, Pamplona R . Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target. Redox Biol. 2019; 23:101082. PMC: 6859548. DOI: 10.1016/j.redox.2018.101082. View

19.

Oeste C, Perez-Sala D . Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function. Mass Spectrom Rev. 2013; 33(2):110-25. DOI: 10.1002/mas.21383. View

20.

Martin-Sierra C, Laranjeira P, Domingues M, Paiva A . Lipoxidation and cancer immunity. Redox Biol. 2019; 23:101103. PMC: 6859558. DOI: 10.1016/j.redox.2019.101103. View