The Long-Term Effects of Ethanol and Corticosterone on the Mood-Related Behaviours and the Balance Between Mature BDNF and ProBDNF in Mice

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2019 May 26

PMID 31127538

Citations 8

Authors

L Y Lin

S Y Luo

M Al-Hawwas

M F Herselman

X F Zhou

Larisa Bobrovskaya

Affiliations

Soon will be listed here.

Abstract

In this study, we aimed to establish the effects of chronic corticosterone (CORT) and ethanol administration on mood-related behaviour and the levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor protein proBDNF in mice. C57BL6 male and female mice received drinking water (n = 22), 1% ethanol in drinking water (n = 16) or 100 μg/ml corticosterone in drinking water (containing 1% ethanol, n = 18) for 4.5 weeks. At the end of experimental protocol, the open field test (OFT) and elevated plus maze test were performed. Brain and adrenal tissues were collected and mBDNF and proBDNF were measured by ELISA assays. We found that the mice fed with corticosterone and ethanol developed anxiety-like behaviours as evidenced by reduced time in the central zone in the OFT compared with the control group. Both proBDNF and mBDNF were significantly decreased in the corticosterone and ethanol groups compared with the control group in the prefrontal cortex, hippocampus, hypothalamus and adrenal. The ratio of proBDNF/mBDNF in prefrontal cortex in the corticosterone group was increased compared with the ethanol group. Our data suggest that the ratio of proBDNF/mBDNF is differentially regulated in different tissues. Ethanol and corticosterone downregulate both mBDNF and proBDNF and alter the balance of proBDNF/mBDNF in some tissues. In conclusion, the ethanol and corticosterone may cause abnormal regulation of mBDNF and proBDNF which may lead to mood disorders.

Citing Articles

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder.

Hu J, Fu J, Cai Y, Chen S, Qu M, Zhang L Exp Biol Med (Maywood). 2024; 249:10129.

PMID: 38993198 PMC: 11236560. DOI: 10.3389/ebm.2024.10129.

Ethanol's impact on the brain: a neurobiological perspective on the mechanisms of memory impairment.

Hedayati-Moghadam M, Razazpour F, Pourfridoni M, Mirzaee F, Baghcheghi Y Mol Biol Rep. 2024; 51(1):782.

PMID: 38918289 DOI: 10.1007/s11033-024-09748-3.

Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain.

Bai X, Batalle G, Martinez-Martel I, Pol O Antioxidants (Basel). 2023; 12(6).

PMID: 37371911 PMC: 10295276. DOI: 10.3390/antiox12061179.

Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle.

Favole A, Testori C, Bergagna S, Gennero M, Ingravalle F, Costa B Animals (Basel). 2023; 13(7).

PMID: 37048423 PMC: 10093196. DOI: 10.3390/ani13071167.

Psychopharmacological properties and therapeutic profile of the antidepressant venlafaxine.

Coutens B, Yrondi A, Rampon C, Guiard B Psychopharmacology (Berl). 2022; 239(9):2735-2752.

PMID: 35947166 DOI: 10.1007/s00213-022-06203-8.

References

Kushner M, Abrams K, Borchardt C . The relationship between anxiety disorders and alcohol use disorders: a review of major perspectives and findings. Clin Psychol Rev. 2000; 20(2):149-71. DOI: 10.1016/s0272-7358(99)00027-6. View

Tapia-Arancibia L, Rage F, Givalois L, Dingeon P, Arancibia S, Beauge F . Effects of alcohol on brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus and hypothalamus. J Neurosci Res. 2001; 63(2):200-8. DOI: 10.1002/1097-4547(20010115)63:2<200::AID-JNR1012>3.0.CO;2-Q. View

Vellucci S, Parrott R, Mimmack M . Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor m RNAs, in the porcine hippocampus after acute dexamethasone treatment. Res Vet Sci. 2001; 70(2):157-62. DOI: 10.1053/rvsc.2001.0456. View

Miller R, King M, Heaton M, Walker D . The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Brain Res. 2002; 950(1-2):137-47. DOI: 10.1016/s0006-8993(02)03014-7. View

Kliethermes C . Anxiety-like behaviors following chronic ethanol exposure. Neurosci Biobehav Rev. 2005; 28(8):837-50. DOI: 10.1016/j.neubiorev.2004.11.001. View

Morris E, Stewart S, Ham L . The relationship between social anxiety disorder and alcohol use disorders: a critical review. Clin Psychol Rev. 2005; 25(6):734-60. DOI: 10.1016/j.cpr.2005.05.004. View

Zhao Y, Ma R, Shen J, Su H, Xing D, Du L . A mouse model of depression induced by repeated corticosterone injections. Eur J Pharmacol. 2008; 581(1-2):113-20. DOI: 10.1016/j.ejphar.2007.12.005. View

Davis M . Ethanol-BDNF interactions: still more questions than answers. Pharmacol Ther. 2008; 118(1):36-57. PMC: 2553254. DOI: 10.1016/j.pharmthera.2008.01.003. View

Pariante C, Lightman S . The HPA axis in major depression: classical theories and new developments. Trends Neurosci. 2008; 31(9):464-8. DOI: 10.1016/j.tins.2008.06.006. View

10.

Gourley S, Kiraly D, Howell J, Olausson P, Taylor J . Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol Psychiatry. 2008; 64(10):884-90. PMC: 2633780. DOI: 10.1016/j.biopsych.2008.06.016. View

11.

Paul C, Au R, Fredman L, Massaro J, Seshadri S, DeCarli C . Association of alcohol consumption with brain volume in the Framingham study. Arch Neurol. 2008; 65(10):1363-7. PMC: 2861346. DOI: 10.1001/archneur.65.10.1363. View

12.

Morris S, Eaves D, Smith A, Nixon K . Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model. Hippocampus. 2009; 20(5):596-607. PMC: 2861155. DOI: 10.1002/hipo.20665. View

13.

Schneier F, Foose T, Hasin D, Heimberg R, Liu S, Grant B . Social anxiety disorder and alcohol use disorder co-morbidity in the National Epidemiologic Survey on Alcohol and Related Conditions. Psychol Med. 2010; 40(6):977-88. PMC: 2917264. DOI: 10.1017/S0033291709991231. View

14.

Xu Z, Zhang Y, Hou B, Gao Y, Wu Y, Zhang C . Chronic corticosterone administration from adolescence through early adulthood attenuates depression-like behaviors in mice. J Affect Disord. 2010; 131(1-3):128-35. DOI: 10.1016/j.jad.2010.11.005. View

15.

Sameti M, Smith S, Patenaude B, Fein G . Subcortical volumes in long-term abstinent alcoholics: associations with psychiatric comorbidity. Alcohol Clin Exp Res. 2011; 35(6):1067-80. PMC: 3097281. DOI: 10.1111/j.1530-0277.2011.01440.x. View

16.

Boden J, Fergusson D . Alcohol and depression. Addiction. 2011; 106(5):906-14. DOI: 10.1111/j.1360-0443.2010.03351.x. View

17.

Frodl T, OKeane V . How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis. 2012; 52:24-37. DOI: 10.1016/j.nbd.2012.03.012. View

18.

Sun Y, Lim Y, Li F, Liu S, Lu J, Haberberger R . ProBDNF collapses neurite outgrowth of primary neurons by activating RhoA. PLoS One. 2012; 7(4):e35883. PMC: 3338794. DOI: 10.1371/journal.pone.0035883. View

19.

Jeanblanc J, Logrip M, Janak P, Ron D . BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2012; 37(4):607-12. PMC: 3577946. DOI: 10.1111/ejn.12067. View

20.

Zhou L, Xiong J, Lim Y, Ruan Y, Huang C, Zhu Y . Upregulation of blood proBDNF and its receptors in major depression. J Affect Disord. 2013; 150(3):776-84. DOI: 10.1016/j.jad.2013.03.002. View