Genomic Insights into a Robust Gamma-aminobutyric Acid-producer Lactobacillus Brevis CD0817

Overview

Journal AMB Express

Date 2019 May 26

PMID 31127390

Citations 20

Authors

Dandan Gao

Kunpeng Chang

Gongtao Ding

Hongjing Wu

Yuanhong Chen

Mengya Jia

Xiaohua Liu

Shuixing Wang

Yuyuan Jin

Hao Pan

Haixing Li

Affiliations

Soon will be listed here.

Abstract

Lactobacillus brevis CD0817, a strain isolated from a healthy adult gut, was currently the most efficient lactic acid bacterial cell factory for gamma-aminobutyric acid. In this study, the complete genome sequence of CD0817 was determined and compared with some related L. brevis genomes. The CD0817 genome consists of one 2,990,570-bp chromosome and four plasmids. The comparative genomic and phylogenetic analysis revealed that L. brevis CD0817 was not very conserved with low GABA-producing L. brevis strains. A significant divergence was that CD0817 harbors only the gadCA operon whereas the low GABA-producing L. brevis strains contain the operon and gadB. The gadB seemed to only marginally contribute to the accumulation of GABA. The high GABA production ability of CD0817 may be associated with its extraordinary genome.

Citing Articles

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