Association of Anemia with Sensorineural Hearing Loss: a Systematic Review and Meta-analysis

Overview

Journal BMC Res Notes

Publisher Biomed Central

Specialties Biology
General Medicine

Date 2019 May 25

PMID 31122277

Citations 11

Authors

Shimel Hussien Mohammed

Sakineh Shab-Bidar

Samer Abuzerr

Tesfa Dejenie Habtewold

Shahab Alizadeh

Kurosh Djafarian

Affiliations

Soon will be listed here.

Abstract

Objective: Evidence shows that anemic individuals are at a higher risk of hearing loss. However, there is no systematic review and meta-analysis study. Thus, we aimed to meta-analyze the existing evidence on the association of iron deficiency anemia (IDA) with sensorineural hearing loss (SNHL). We searched PubMed, MEDLINE, Embase, Scopus, and Google Scholar from inception through October 30, 2017, for studies done on the association of the IDA with SNHL. Pooled odds ratio (OR) was calculated by random effect meta-analysis method. Heterogeneity was assessed by I metrics.

Result: Four studies, covering a total of 344,080 adults and children, were included. The odds of SNHL was higher by 55% in individuals with IDA, compared with individuals without IDA (OR = 1.55, 95% CI 1.17-2.06; P = 0.03). The age-specific ORs were 1.36 (95% CI 1.15-1.61; P = 0.27) and 3.67 (95% CI 1.72-7.84) for adults and children, respectively. IDA may be a contributing factor to hearing loss. Further studies are warranted, including whether IDA treatment reduces the risk of hearing loss. Meanwhile, hearing loss screening in anemic individuals, or vice versa, may represent an important consideration. PROSPERO registration CRD42017082108.

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References

Stroup D, Berlin J, Morton S, Olkin I, Williamson G, Rennie D . Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000; 283(15):2008-12. DOI: 10.1001/jama.283.15.2008. View

Higgins J, Thompson S . Quantifying heterogeneity in a meta-analysis. Stat Med. 2002; 21(11):1539-58. DOI: 10.1002/sim.1186. View

Wake M, Hughes E, Poulakis Z, Collins C, Rickards F . Outcomes of children with mild-profound congenital hearing loss at 7 to 8 years: a population study. Ear Hear. 2004; 25(1):1-8. DOI: 10.1097/01.AUD.0000111262.12219.2F. View

Badaracco M, Ortiz E, Soto E, Connor J, Pasquini J . Effect of transferrin on hypomyelination induced by iron deficiency. J Neurosci Res. 2008; 86(12):2663-73. DOI: 10.1002/jnr.21709. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010; 8(5):336-41. DOI: 10.1016/j.ijsu.2010.02.007. View

Schmitz J, Pillion J, LeClerq S, Khatry S, Wu L, Prasad R . Prevalence of hearing loss and ear morbidity among adolescents and young adults in rural southern Nepal. Int J Audiol. 2010; 49(5):388-94. DOI: 10.3109/14992020903555708. View

Stang A . Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010; 25(9):603-5. DOI: 10.1007/s10654-010-9491-z. View

Nash S, Cruickshanks K, Klein R, Klein B, Nieto F, Huang G . The prevalence of hearing impairment and associated risk factors: the Beaver Dam Offspring Study. Arch Otolaryngol Head Neck Surg. 2011; 137(5):432-9. PMC: 3096733. DOI: 10.1001/archoto.2011.15. View

Stevens G, Flaxman S, Brunskill E, Mascarenhas M, Mathers C, Finucane M . Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries. Eur J Public Health. 2011; 23(1):146-52. DOI: 10.1093/eurpub/ckr176. View

10.

Kahlon N, Gandhi A, Mondal S, Narayan S . Effect of iron deficiency anemia on audiovisual reaction time in adolescent girls. Indian J Physiol Pharmacol. 2012; 55(1):53-9. View

11.

Dubyk M, Card R, Whiting S, Boyle C, Zlotkin S, Paterson P . Iron deficiency anemia prevalence at first stroke or transient ischemic attack. Can J Neurol Sci. 2012; 39(2):189-95. DOI: 10.1017/s0317167100013214. View

12.

Kassebaum N, Jasrasaria R, Naghavi M, Wulf S, Johns N, Lozano R . A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2013; 123(5):615-24. PMC: 3907750. DOI: 10.1182/blood-2013-06-508325. View

13.

Chung S, Chen P, Lin H, Hung S . Sudden sensorineural hearing loss associated with iron-deficiency anemia: a population-based study. JAMA Otolaryngol Head Neck Surg. 2014; 140(5):417-22. DOI: 10.1001/jamaoto.2014.75. View

14.

Olusanya B, Neumann K, Saunders J . The global burden of disabling hearing impairment: a call to action. Bull World Health Organ. 2014; 92(5):367-73. PMC: 4007124. DOI: 10.2471/BLT.13.128728. View

15.

Zhang C . Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell. 2014; 5(10):750-60. PMC: 4180463. DOI: 10.1007/s13238-014-0083-7. View

16.

Emmett S, Francis H . The socioeconomic impact of hearing loss in U.S. adults. Otol Neurotol. 2014; 36(3):545-50. PMC: 4466103. DOI: 10.1097/MAO.0000000000000562. View

17.

McGuire S . World Health Organization. Comprehensive Implementation Plan on Maternal, Infant, and Young Child Nutrition. Geneva, Switzerland, 2014. Adv Nutr. 2015; 6(1):134-5. PMC: 4288273. DOI: 10.3945/an.114.007781. View

18.

Deal J, Sharrett A, Albert M, Coresh J, Mosley T, Knopman D . Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study. Am J Epidemiol. 2015; 181(9):680-90. PMC: 4408947. DOI: 10.1093/aje/kwu333. View

19.

Camaschella C . Iron-deficiency anemia. N Engl J Med. 2015; 372(19):1832-43. DOI: 10.1056/NEJMra1401038. View

20.

Leverton T . Hearing loss is important in dementia. BMJ. 2015; 350:h3650. DOI: 10.1136/bmj.h3650. View