» Articles » PMID: 3112076

Occurrence of Tumor-associated Ganglioside Antigens with Hanganutziu-Deicher Antigenic Activity on Human Melanomas

Overview
Specialty Oncology
Date 1987 Jun 1
PMID 3112076
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

The specificity of antibody to NeuGc alpha 2-3Gal beta 1-4Glc-cer (GM3(NeuGc] was carefully reexamined by the method of enzyme-immunostaining on a thin layer plate. The affinity-purified antibody was found to react with NeuGc alpha 2-8NeuGc alpha 2-3Gal beta 1-4Glc-cer (GD3(NeuGc-NeuGc] and NeuGc alpha 2-8NeuAc alpha 2-3Gal beta 1-4Glc-cer (GD3(NeuGc-NeuAc], but not with NeuAc alpha 2-8NeuGc alpha 2-3Gal beta 1-4Glc-cer (GD3(NeuAc-NeuGc)) or NeuAc alpha 2-8NeuAc alpha 2-3Gal beta 1-4Glc-cer (GD3(NeuAc-NeuAc]. From this result together with the previous results, it (GD3(NeuAc-NeuAc], From this result together with the previous results, it could be concluded that the antibody recognizes the outer portion of molecular species of sialic acids in the gangliosides. By using this antibody, the expression of Hanganutziu-Deicher (HD) gangliosides could be demonstrated in human malignant melanoma. The molecular species were different among individuals examined. Among HD-antigenic gangliosides, GM3(NeuGc) was commonly found in melanoma tissues. One of the patients examined expressed GD3(NeuGc-NeuGc) and GD 3(NeuGc-NeuAc), which may be characteristic gangliosides in human melanomas, since these gangliosides could not be detected in human colon cancer or human fetal tissues.

Citing Articles

The Role of Non-Human Sialic Acid Neu5Gc-Containing Glycoconjugates in Human Tumors: A Review of Clinical and Experimental Evidence.

Blanco R, Munoz J Biomolecules. 2025; 15(2).

PMID: 40001556 PMC: 11853303. DOI: 10.3390/biom15020253.


Cs γ Ray and Si Irradiation Induced Murine Hepatocellular Carcinoma Lipid Changes in Liver Assessed by MALDI-MSI Combined with Spatial Shrunken Centroid Clustering Algorithm: A Pilot Study.

Nia A, Shavkunov A, Ullrich R, Emmett M ACS Omega. 2020; 5(39):25164-25174.

PMID: 33043195 PMC: 7542585. DOI: 10.1021/acsomega.0c03047.


Intestine specific regulation of pig cytidine-5'-monophospho-N-acetylneuraminic acid hydroxylase gene for N-glycolylneuraminic acid biosynthesis.

Song K, Kwak C, Chung T, Ha S, Park J, Ha K Sci Rep. 2019; 9(1):4292.

PMID: 30862964 PMC: 6414617. DOI: 10.1038/s41598-019-40522-9.


Recombinant AAV-mediated in vivo long-term expression and antitumour activity of an anti-ganglioside GM3(Neu5Gc) antibody.

Piperno G, Lopez-Requena A, Predonzani A, Dorvignit D, Labrada M, Zentilin L Gene Ther. 2015; 22(12):960-7.

PMID: 26181624 DOI: 10.1038/gt.2015.71.


Molecular recognition of gangliosides and their potential for cancer immunotherapies.

Krengel U, Bousquet P Front Immunol. 2014; 5:325.

PMID: 25101077 PMC: 4104838. DOI: 10.3389/fimmu.2014.00325.