Genetic Associations Between the MiRNA Polymorphisms MiR-130b (rs373001), MiR-200b (rs7549819), and MiR-495 (rs2281611) and Colorectal Cancer Susceptibility

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2019 May 24

PMID 31117970

Citations 4

Authors

Eun-Gyo Kim

Jung Oh Kim

Han Sung Park

Chang Soo Ryu

Jisu Oh

Hak Hoon Jun

Jong Woo Kim

Nam Keun Kim

Affiliations

Soon will be listed here.

Abstract

Background: Recent studies have extensively investigated the role of miRNAs in colorectal cancer (CRC), and several associations have been reported. In addition, single nucleotide polymorphisms (SNPs) in promoter regions of miRNAs have been shown to affect miRNA expression. Therefore, we aimed to analyze the effect of miRNA polymorphisms on CRC susceptibility.

Methods: We conducted association studies on the relationships between the miRNA polymorphisms miR-130bT > C rs373001, miR-200bT > C rs7549819, and miR-495A > C rs2281611 and CRC with 472 CRC patients and 399 control subjects in Korea.

Results: Multivariate logistic regressions of the CRC subgroups showed that the miR-495CC genotype associated with rectal cancer (AA+AC vs. CC; adjusted odds ratio (AOR) for CC, 1.592; 95% confidence interval (CI), 1.071-2.368; P = 0.022). The gene-environment combinatorial analysis showed that the combination of miR-495A > C and low plasma folate contributed to an increased risk of rectal cancer (AA+AC vs. CC; AOR for CC, 3.829; 95% CI, 1.577-9.300; P = 0.003). In the survival analysis, miR-200bT > C associated with CRC patient mortality (TT vs TC + CC; adjusted hazard ratio for TC + CC, 0.592; 95% CI, 0.373-0.940; P = 0.026).

Conclusion: In this study, we found that miR-200b and miR-495 polymorphisms are involved in CRC susceptibility and prognosis.

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