Updates on Aptamer Research

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 May 24

PMID 31117311

Citations 59

Authors

Mohamed H Ali

Marwa E Elsherbiny

Marwan Emara

Affiliations

Soon will be listed here.

Abstract

For many years, different probing techniques have mainly relied on antibodies for molecular recognition. However, with the discovery of aptamers, this has changed. The science community is currently considering using aptamers in molecular targeting studies because of the many potential advantages they have over traditional antibodies. Some of these possible advantages are their specificity, higher binding affinity, better target discrimination, minimized batch-to-batch variation, and reduced side effects. Overall, these characteristics of aptamers have attracted scholars to use them as molecular probes in place of antibodies, with some aptamer-based targeting products being now available in the market. The present review is aimed at discussing the potential of aptamers as probes in molecular biology and in super-resolution microscopy.

Citing Articles

Aptamers: precision tools for diagnosing and treating infectious diseases.

Sujith S, Naresh R, Srivisanth B, Sajeevan A, Rajaramon S, David H Front Cell Infect Microbiol. 2024; 14:1402932.

PMID: 39386170 PMC: 11461471. DOI: 10.3389/fcimb.2024.1402932.

Recent advances in surface plasmon resonance for the detection of ovarian cancer biomarkers: a thorough review.

Shahbazlou S, Vandghanooni S, Dabirmanesh B, Eskandani M, Hasannia S Mikrochim Acta. 2024; 191(11):659.

PMID: 39382786 DOI: 10.1007/s00604-024-06740-3.

Novel Aptamer Strategies in Combating Bacterial Infections: From Diagnostics to Therapeutics.

Ye Z, Chen H, Weinans H, van der Wal B, Rios J Pharmaceutics. 2024; 16(9).

PMID: 39339177 PMC: 11435160. DOI: 10.3390/pharmaceutics16091140.

Crossing the Halfway Point: Aptamer-Based, Highly Multiplexed Assay for the Assessment of the Proteome.

Kraemer S, Schneider D, Paterson C, Perry D, Westacott M, Hagar Y J Proteome Res. 2024; 23(11):4771-4788.

PMID: 39038188 PMC: 11536431. DOI: 10.1021/acs.jproteome.4c00411.

Boronic functionalized aptamer macroarrays with dual-recognition and isothermal amplification of lipopolysaccharide detection.

Zhang Q, Wang Y, Ma D, Pan X, Sheng E, Shen J Mikrochim Acta. 2024; 191(8):476.

PMID: 39037471 DOI: 10.1007/s00604-024-06567-y.

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