Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2019 May 24

PMID 31117194

Citations 14

Authors

Marta Camacho-Cardenosa

Alba Camacho-Cardenosa

Rafael Timon

Guillermo Olcina

Pablo Tomas-Carus

Javier Brazo-Sayavera

Affiliations

Soon will be listed here.

Abstract

Among other functions, hypoxia-inducible factor plays a critical role in bone-vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambient oxygen on bone remodelling parameters of healthy organisms. Thirty-nine studies analysed the effect of sustained or cyclic hypoxia exposure on genetic and protein expression and mineralisation capacity of different cell models; three studies carried out in animal models implemented sustained or cyclic hypoxia; ten studies examined the effect of sustained, intermittent or cyclic hypoxia on bone health and hormonal responses in humans. Different modes of hypoxic conditioning may have different impacts on bone metabolism both in vivo and in vitro. Additional research is necessary to establish the optimal cyclical dose of oxygen concentration and exposure time.

Citing Articles

The Effect of Heparin on Bone Metabolism and Orthodontic Tooth Movement in Rats.

Salari B, Moradian R, Kheirandish Y, Alaeddini M, Etemad-Moghadam S, Maghsoudi S Clin Exp Dent Res. 2025; 11(1):e70061.

PMID: 40066602 PMC: 11894433. DOI: 10.1002/cre2.70061.

Combined Effects of Cyclic Hypoxic and Mechanical Stimuli on Human Bone Marrow Mesenchymal Stem Cell Differentiation: A New Approach to the Treatment of Bone Loss.

Camacho-Cardenosa M, Pulido-Escribano V, Torrecillas-Baena B, Quesada-Gomez J, Herrera-Martinez A, Sola-Guirado R J Clin Med. 2024; 13(19).

PMID: 39407866 PMC: 11476683. DOI: 10.3390/jcm13195805.

Impact of altitude on the development of low bone mineral density and osteoporosis in individuals aged 50 years and older: protocol for a multicentre prospective cohort study.

Zhang F, Chen Y, Wang S, Shi Z, Zhong Y, Zhu S BMJ Open. 2024; 14(8):e087142.

PMID: 39181552 PMC: 11344496. DOI: 10.1136/bmjopen-2024-087142.

Construction of Bone Hypoxic Microenvironment Based on Bone-on-a-Chip Platforms.

Li C, Zhao R, Yang H, Ren L Int J Mol Sci. 2023; 24(8).

PMID: 37108162 PMC: 10139217. DOI: 10.3390/ijms24086999.

Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study.

Liu X, Ma C, Wang S, Liang Z, Yang J, Zhou J Front Endocrinol (Lausanne). 2022; 13:1010102.

PMID: 36452328 PMC: 9704050. DOI: 10.3389/fendo.2022.1010102.

References

Salamanna F, Cepollaro S, Contartese D, Giavaresi G, Barbanti Brodano G, Griffoni C . Biological Rationale for the Use of Vertebral Whole Bone Marrow in Spinal Surgery. Spine (Phila Pa 1976). 2018; 43(20):1401-1410. DOI: 10.1097/BRS.0000000000002626. View

Lee J, Park J, Kim T, Jung B, Lee Y, Shim E . Human bone marrow stem cells cultured under hypoxic conditions present altered characteristics and enhanced in vivo tissue regeneration. Bone. 2015; 78:34-45. DOI: 10.1016/j.bone.2015.04.044. View

Aghajanian P, Hall S, Wongworawat M, Mohan S . The Roles and Mechanisms of Actions of Vitamin C in Bone: New Developments. J Bone Miner Res. 2015; 30(11):1945-55. PMC: 4833003. DOI: 10.1002/jbmr.2709. View

Bouvard B, Abed E, Yelehe-Okouma M, Bianchi A, Mainard D, Netter P . Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts. Arthritis Res Ther. 2014; 16(5):459. PMC: 4302570. DOI: 10.1186/s13075-014-0459-3. View

Lee S, Gardner A, Kalinowski J, Jastrzebski S, Lorenzo J . RANKL-stimulated osteoclast-like cell formation in vitro is partially dependent on endogenous interleukin-1 production. Bone. 2005; 38(5):678-85. DOI: 10.1016/j.bone.2005.10.011. View

Kalinina N, Kharlampieva D, Loguinova M, Butenko I, Pobeguts O, Efimenko A . Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes. Stem Cell Res Ther. 2015; 6:221. PMC: 4642680. DOI: 10.1186/s13287-015-0209-8. View

Merceron C, Vinatier C, Portron S, Masson M, Amiaud J, Guigand L . Differential effects of hypoxia on osteochondrogenic potential of human adipose-derived stem cells. Am J Physiol Cell Physiol. 2009; 298(2):C355-64. DOI: 10.1152/ajpcell.00398.2009. View

Gordillo G, Sen C . Revisiting the essential role of oxygen in wound healing. Am J Surg. 2003; 186(3):259-63. DOI: 10.1016/s0002-9610(03)00211-3. View

Wang G, Wang J, Sun D, Xin J, Wang L, Huang D . Short-Term Hypoxia Accelerates Bone Loss in Ovariectomized Rats by Suppressing Osteoblastogenesis but Enhancing Osteoclastogenesis. Med Sci Monit. 2016; 22:2962-71. PMC: 5006713. DOI: 10.12659/msm.899485. View

10.

Mateika J, El-Chami M, Shaheen D, Ivers B . Intermittent hypoxia: a low-risk research tool with therapeutic value in humans. J Appl Physiol (1985). 2015; 118(5):520-32. DOI: 10.1152/japplphysiol.00564.2014. View

11.

Pattappa G, Thorpe S, Jegard N, Heywood H, de Bruijn J, Lee D . Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells. Tissue Eng Part C Methods. 2012; 19(1):68-79. DOI: 10.1089/ten.TEC.2011.0734. View

12.

Martin-Rendon E, Hale S, Ryan D, Baban D, Forde S, Roubelakis M . Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia. Stem Cells. 2006; 25(4):1003-12. DOI: 10.1634/stemcells.2006-0398. View

13.

Burian E, Probst F, Palla B, Riedel C, Saller M, Cornelsen M . Effect of hypoxia on the proliferation of porcine bone marrow-derived mesenchymal stem cells and adipose-derived mesenchymal stem cells in 2- and 3-dimensional culture. J Craniomaxillofac Surg. 2017; 45(3):414-419. DOI: 10.1016/j.jcms.2016.12.014. View

14.

Lavie L . Obstructive sleep apnoea syndrome--an oxidative stress disorder. Sleep Med Rev. 2003; 7(1):35-51. DOI: 10.1053/smrv.2002.0261. View

15.

Serebrovska T, Serebrovska Z, Egorov E . Fitness and therapeutic potential of intermittent hypoxia training: a matter of dose. Fiziol Zh (1994). 2018; 62(3):78-91. DOI: 10.15407/fz62.03.078. View

16.

Bozzini C, Lezon C, Norese M, Conti M, Martinez M, Olivera M . Evidence from catch-up growth and hoarding behavior of rats that exposure to hypobaric air lowers the body-mass set point. Growth Dev Aging. 2006; 69(2):81-8. View

17.

Sengupta S, Park S, Patel A, Carn J, Lee K, Kaplan D . Hypoxia and amino acid supplementation synergistically promote the osteogenesis of human mesenchymal stem cells on silk protein scaffolds. Tissue Eng Part A. 2010; 16(12):3623-34. PMC: 2991219. DOI: 10.1089/ten.TEA.2010.0302. View

18.

Kelly L, Basset F . Acute Normobaric Hypoxia Increases Post-exercise Lipid Oxidation in Healthy Males. Front Physiol. 2017; 8:293. PMC: 5434119. DOI: 10.3389/fphys.2017.00293. View

19.

Litovka I . [Alimentary and oxygen deprivation as the modulator of the bone tissue physiological remodelling rate in young rats]. Fiziol Zh (1994). 2008; 54(1):85-93. View

20.

Urdampilleta A, Gonzalez-Muniesa P, Portillo M, Martinez J . Usefulness of combining intermittent hypoxia and physical exercise in the treatment of obesity. J Physiol Biochem. 2011; 68(2):289-304. DOI: 10.1007/s13105-011-0115-1. View